We prove in this paper a noncommutative version of Leray Theorem and then Serre Spectral Theorem for noncommutative Serre fibrations. We prove that for NC Serre fibration there are converging spectral sequences with E2 terms as E2 p,q = HPp(B,A;HPq(A)) =⇒ HPp+q(B) and E 2 p,q = HPp(B,A;Kq(A)) =⇒ Kp+q(B). Introduction The ideas of using spectral sequences to operator algebras was started in [C]....