نتایج جستجو برای: pyruvate dehydrogenase kinase 4 endurance training metabolic flexibility estrogen
تعداد نتایج: 2123275 فیلتر نتایج به سال:
Recent research suggests that LKB1 is the major AMP-activated protein kinase kinase (AMPKK). Peroxisome-proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) is a master coordinator of mitochondrial biogenesis. Previously we reported that skeletal muscle LKB1 protein increases with endurance training. The purpose of this study was to determine whether training-induced increases ...
Hemodynamic forces regulate vascular functions. Disturbed flow (DF) occurs in arterial bifurcations and curvatures, activates endothelial cells (ECs), and results in vascular inflammation and ultimately atherosclerosis. However, how DF alters EC metabolism, and whether resulting metabolic changes induce EC activation, is unknown. Using transcriptomics and bioenergetic analysis, we discovered th...
Background and Objective: The proportional practice protocol is an important issue for middle-aged women to start a health and energetic life style. Aerobic training is proposed as the first and best method of practice for all individuals. However, this protocol is not without damage, because this method like other methods can lead to some cellular disorders, especially muscle cell disorde...
Numerous human in vivo studies on skeletal muscle gene expression have investigated the effects of given interventions. These have been founded on the assumption that presampling can be regarded as a representative control for postintervention sampling. However, many genes are responsive to the metabolic status, which varies during the day, so that observed differences in gene expression betwee...
We aimed to further investigate mitochondrial adaptations to muscle disuse and the consequent metabolic disorders. Male rats were submitted to hindlimb unloading (HU) for three weeks. Interestingly, HU increased insulin sensitivity index (ISI) and decreased blood level of triglyceride and insulin. In skeletal muscle, HU decreased expression of pyruvate dehydrogenase kinase 4 (PDK4) and its prot...
The prolyl-4-hydroxylase domain (PHD) enzymes are regarded as the molecular oxygen sensors. There is an interplay between oxygen availability and cellular metabolism, which in turn has significant effects on the functionality of innate immune cells, such as macrophages. However, if and how PHD enzymes affect macrophage metabolism are enigmatic. We hypothesized that macrophage metabolism and fun...
Background and Objectives: Adipokines as lipid-secreted proteins play an important role in controlling the metabolism of the body. The aim of the present study was to investigate the effects of ERRα (Estrogen-related receptor alpha) inhibition on the serum levels of Chemerin, Nesfatin-1 ,and Apelin after 4 weeks of endurance training in male Wistar rats. Materials and Methods: In this ex...
1. Insulin prevented increases in liver glucose 6-phosphatase and fructose 1,6-diphosphatase activities in response to cortisol administration, but it did not prevent increases in response to diets high in protein or in fructose. 2. Insulin increased pyruvate kinase activity in animals treated with cortisol or fed a high protein diet; both treatments decrease pyruvate kinase activity. Insulin d...
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