Several 5-substituted 2-pyrimidinone 2'-deoxyribonucleoside (PdR) analogs were examined for their anti-herpes simplex virus (HSV) activity in cell culture. The order of potency of their antiviral activities against HSV type 1 (HSV-1) and HSV-2 was iodo PdR approximately ethynyl PdR approximately propynyl PdR. The antiviral action of iodo PdR is dependent on the ability of HSV to induce virus-sp...

In the title compound, C(18)H(15)N(3)O(3)·0.5CH(2)Cl(2), the fused ring benzofuro[2,3-d]pyrimidine system is essentially planar [maximum deviation 0.029 (1) Å]. The planes of the pyrimidinone and phenyl rings are nearly perpendicular [dihedral angle = 87.50 (14)°]. The packing of the mol-ecules in the crystal structure is governed mainly by inter-molecular O-H⋯O and N-H⋯O hydrogen-bonding inter...

The asymmetric unit of the title compound, C(22)H(16)ClN(3)O(5), consists of two crystallographically independent mol-ecules. The fused rings of the imidazo[1,2-a]benzo[4,5]furo[3,2-d]pyrimidine system are nearly coplanar and the chlorophenyl rings are twisted with respect to the two pyrimidinone ring systems by 71.00 (2) and 62.59 (2)°. The C atoms of the ethyl side chain are disordered and we...

A new strategy for synthesizing well-defined, chain-end-functionalized polymers containing multiple hydrogen-bonding (MHB) groups capable of heterodimerization in both solution and the melt has been developed. Two complementary MHB systems were chosen for initial studies: 2-ureido-4[1H]-pyrimidinone (UPy) and 2,7diamido-1,8-naphthyridine (Napy) and ATRP initiators containing either UPy or Napy ...

Titanium implants are widely used in medicine but have a risk of biomaterial-associated infection (BAI), which traditional antibiotic-based treatment is affected by resistance. Antimicrobial peptides (AMPs) to successfully kill antibiotic-resistant bacteria. Herein, supramolecular coating for titanium developed presents the synthetic antimicrobial and antibiofilm peptide SAAP-148 via interactio...