The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...

The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...

In a previous paper (Hughes, Bower, Raine, and Syed, 1966) it was shown that about one-third of patients with childhood epilepsy showed, on admission, an abnormality of tryptophan metabolism characterized by a high excretion of xanthurenic acid inthe urine followingan oral load oftryptophan. This is usually accompanied by high excretion of certain other metabolites of tryptophan having in commo...

The first naturally occurring form of vitamin B6 was isolated in 1938. It has the structure, confirmed by chemical synthesis (1939), of 3-hydroxy-4,5-bis(hydroxymethyl)-2-methylpyridine (I; R = -CHzOH). The trivial name “pyridoxine,” proposed for this compound by P. GyGrgy, came into general use as a synonym for “vitamin Be.” Two other natural compounds possessing vitamin B6 activity, detected ...

A simple, rapid, accurate and precise spectrophotometric method is proposed for determination of pyridoxine hydrochloride (Vitamin B6) in pure form and in its pharmaceutical preparations and serum. The method is based on the oxidation-reduction reaction between vitamin B6 and cerium (IV) ion (ceric ion), then the subsequent reaction of cerium (III) with arsenazo III reagent in acidic medium in ...

BACKGROUND Migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. There are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. Hence, this study aimed to assess the effects of pyridoxine supplementation on severity, frequency and duration of migraine attacks as well as headac...

A relation between pyridoxine and convulsive phenomena has been established over several years (Snyderman, Holt, Carretero, and Jacobs, 1953; Molony and Parmelee, 1954; Adams, Bessey, Bussey, and Hansen, 1954; May, 1954; Coursin, 1954, 1955). This led to a search for evidence of pyridoxine deficiency among children with cryptogenic epilepsy. Soon patients were discovered who, though receiving a...

The factors which govern the absorption of iron are not well understood. The current theory of iron absorption assigns to bodily need for iron the chief role in the regulation of iron absorption (1, 2). Conclusive evidence is needed, however, to demonstrate the correctness of such a view. In an earlier study from this laboratory (3), it was demonstrated that the high serum iron values and hemos...