This study establishes a new trans-metal-trapping (TMT) procedure based on a mixture of LiTMP (the base) and tris(trimethylsilylmethyl)gallium [Ga(CH2 SiMe3 )3 , GaR3 ] (the trap) that, operating in a tandem manner, is effective for the regioselective deprotonation of sensitive diazines in hydrocarbon solution, as illustrated through reactions of pyrazine, pyridazine, and pyrimidine, as well as...

In the title mol-ecule, C14H18ClN5O2S, the six atoms of the 1,6-di-hydro-pyridazine ring are essentially coplanar (r.m.s. deviation = 0.008 Å), and the dihedral angle between this and the 1,3,4-thia-diazole ring is 62.06 (10)°. In the crystal, centrosymmetrically related mol-ecules are linked by inter-molecular C-H-O hydrogen bonding to form a supra-molecular dimer. The terminal ethyl group is ...

The triclinic unit cell of the title compound, N(2)H(6) (2+)·2C(6)H(3)N(2)O(4) (-)·2H(2)O, contains one doubly protonated hydrazine cation which lies on an inversion centre, two symmetry-related singly deprotonated 6-carboxy-pyridazine-3-carboxyl-ate anions and two symmetry-related solvent water mol-ecules. The anions inter-act via hydrogen bonds to form double ribbons which are bridged by hydr...

The mol-ecule of title compound, C(13)H(11)N(5), is essentially planar (r.m.s. deviation = 0.0440 Å) and an intra-molecular C-H⋯N hydrogen bond generates an S(6) motif. In the crystal, mol-ecules are connected into chains by inter-molecular N-H⋯N and C-H⋯N hydrogen bonds. In addition, π-π stacking inter-actions are observed between the pyrazole and pyridazine rings [inter-planar distance = 3.68...

The inhibitory action of some herbicides on photosynthetic electron flow at photosystem II in isolated chloroplasts was investigated. Emphasis in the study is on compounds, whose chemical structure seemed to be in disaccordance with the basic structural element, proposed to be required for a photosystem II inhibitor. The effective inhibition of photosynthetic oxygen evolution by N-alkylated ure...

Two independent mol-ecules are present in the asymmetric unit of the title compound, C(12)H(11)ClN(4), (Z' = 2): the dihedral angles between the phenyl and pyridizine rings are 8.35 (10) and 37.64 (6)°. In the crystal, the two mol-ecules form inversion dimers with R(2) (2)(8) ring motifs through inter-molecular N-H⋯N hydrogen bonds. The crystal structure is stabilized by π-π inter-actions betwe...

The arylmethylidene derivatives of furan-2(3H)-ones are important building blocks for the synthesis of various heterocyclic compounds containing pyrimidine and pyridazine structural fragments, analogues of nitrogen-containing bases of pyrimidine series. In order to continue the development of constructing of molecules containing pyridine and pyridazine fragments, this article is devoted to the ...

N-Aryl-C-ethoxycarbonylnitrile imines (3a-g) react with ethyl cyanoacetate 1 in 1,3-dipolar cycloaddition to yield novel pyrazole-3,4-dicarboxylates (4a-g) in moderate yields. The reaction of pyrazole-3,4-dicarboxylates (4a, d) with hydrazine afforded pyrazolo[4,3-d]pyridazine-4,7-diones (5a, d) in good yields. All compounds were fully characterized by spectroscopic methods. Some of the newly s...

The reaction of phenylhydrazoethyl acetoacetate (1) with cyanoacetyl hydrazine (2) in an oil bath in the presence of ammonium acetate gave the pyridazine derivative 4. However, carrying the same reaction but in ethanolic/Et3N gave the pyrazole derivative 5. Compounds 4 and 5 were used in a series of heterocyclization reactions to afford products that showed anti-tumor activities towards three c...

In the title structure, [Pb(C(5)H(3)N(2)O(2))(2)](n), the Pb(II) ion is six-coordinated by two pyridazine-3-carboxyl-ate ligands via N and O atoms, with the carboxyl-ato O atoms acting as bidentate and bridging adjacent Pb(II) ions, giving rise to catenated mol-ecular ribbons propagating along the a-axis direction. The ribbons are connected by C-H⋯O hydrogen bonds and van der Waals inter-actions.