A series of novel pyrazoline derivatives 5-(substituted aryl)-3-(3,4-dimethoxyphenyl)-1-(2,4dinitrophenyl)-4,5-dihydro-1H-pyrazole (5a-l) were synthesized by heating 2,4-dinitrophenyl hydrazine (4) with (E)-3-(3,4-dimethoxyphenyl)-1-substituted aryl prop-2-en-1-one (3) in presence of catalytic amount of concentrated H2SO4. The structures of the novel derivatives were confirmed by various spectr...

The intramolecular [3+2] cycloaddition (32CA) of alkene-tethered α-silyloxydiazoalkanes provides variable stereoselectivity in generating bicyclic pyrazolines where the silyloxy group is either syn or anti to the newly formed pyrazoline ring. To elucidate the origin of the stereoselectivity, density functional theory (DFT) calculations were carried out for the energy of each transition state st...

In the title compound, C20H18N2O2, the central pyrazoline ring has an envelope conformation with the atom substituted by the naphthalene ring as the flap. It bridges a benzene ring and a naphthalene ring system which are almost normal to one another, making a dihedral angle of 82.03 (6) °. There is an intra-molecular O-H⋯N hydrogen bond forming an S(6) ring motif. In the crystal, mol-ecules are...

Four independent mol-ecules comprise the asymmetric unit of the title compound, C(17)H(14)N(2)O(2). The central pyrazoline ring is flanked by an N-bound benzene ring and a C-bound meth-oxy-substituted benzene ring. The greatest difference between the independent mol-ecules is found in the relative orientations of the benzene rings with the range of dihedral angles being 23.59 (6)-42.55 (6)°. In...

Pyrazolines and pyrazolidines represent two important classes of five-membered N-heterocycles found in many natural products, agrochemicals and biologically active molecules. Over the past decades, tremendous efforts have been devoted to the development of efficient methods for efficient construction of these scaffolds. However, the catalytic asymmetric synthesis of pyrazolines and pyrazolidine...

Objective: The present work is based on the above pyrazoline derivative form heterocyclic substituted chalcone. Methods: elemental analysis, IR, 1H and 13C NMR mass spectrum analyses were used to characterise structures of obtained compounds. Results: scheme-1 scheme-2 describe synthesis chalcone (thiophene-fluorenyl derivative) pyrazolines respectively. Chalcone has been synthesized from 2-Ace...

Pyrazolines, which are nitrogen including five-membered heterocyclic structures, have been used in the organic and pharmaceutical industries. This study aimed was to synthesize characterizes new series of 3,5-diphenyl-4,5-dihydro-1H-pyrazole derivatives. The pyrazoline compounds synthesized from chalcones hydrazine hydrate two steps. In first step, were 2-amino acetophenone various substituted ...