the association of hla and disease varies in different populations. we have . studied the association of hla class i in iranian psoriatic patients, in order to compare this association with other reports. fifty-one iranian patients with psoriasis were hla typed. the frequency of hla antigens in patients and patient subgroups, based on clinical patterns, age of onset, family history and provocat...

Introduction The CARD14 (Caspase Recruitment Family Member 14) locus encodes a scaffold protein that mediates NF-kB signalling in keratinocytes and is therefore crucial to the maintenance of skin immune homeostasis. In keeping with this notion, gain-of-function CARD14 mutations have been observed in patients with plaque psoriasis and pityriasis rubra pilaris, two skin disorders mediated by abno...

Psoriasis is an autoimmune disease triggered by different conditions in genetically susceptible people. It is characterized by variable cutaneous manifestations including localized or disseminated pustules. Generalized pustular psoriasis (GPP) has two main clinical forms: von Zumbusch psoriasis, characterized by severe erythrodermia and scaling skin after the resolution of pustules, and the ann...

Severe cutaneous drug reactions include a wide spectrum of clinical manifestations ranging from mild morbilliform cutaneous rash, to severe forms of hypersensitivity. Special attention is given in this report to the acute generalized exanthematous pustulosis (AGEP), induced in 90% of cases by the use of systemic drugs, especially aminopenicillins and macrolides. The incidence of the disease is ...

Psoriasis is a chronic inflammatory skin disease with complex pathogenesis involving the interaction between innate and adaptive immune systems. The release of antimicrobial peptides (AMPs) by keratinocytes, particularly LL-37 peptides, plays crucial role in initiation psoriatic inflammation. activation dendritic cells distinct T-cell subsets, Th1 Th17, leads to formation scaly plaques psoriasi...

The association of HLA and disease varies in different populations. We have . studied the association of HLA class I in Iranian psoriatic patients, in order to compare this association with other reports. Fifty-one Iranian patients with psoriasis were HLA typed. The frequency of HLA antigens in patients and patient subgroups, based on clinical patterns, age of onset, family history and prov...

IMPORTANCE Golimumab is a human monoclonal antibody, used for rheumatoid arthritis, psoriatic arthritis and ankylosing spondylitis. Adverse reactions are increasing with this class of medication (tumor necrosis factor α inhibitors). OBSERVATIONS The authors present a case of a female patient who presented with psoriasis pustulosa after the use of golimumab for rheumatoid arthritis. CONCLUSI...

Lithium has been implicated in the exacerbation of pre-existing psoriasis, in the induction of psoriasis on previously uninvolved skin of psoriasis patients, and in the triggering of psoriasis for the first time in patients without a personal or family history. Lithium-induced psoriasis (and its resistance to treatment) is one of the major reasons for noncompliance in patients treated with lith...

Anti-tumor necrosis factor (TNF)-α antibody is utilized in the treatment of a variety of chronic inflammatory conditions, including psoriasis. However, it can induce paradoxical development and/or exacerbation of psoriasis in the course of anti-TNF-α antibody treatment, which is sometimes refractory to conventional treatments. Herein, we report a case of refractory palmoplantar pustular psorias...