Featured Article: Lilja H, Christensson A, Dahlen U, et al. Prostate-Specific Antigen in Serum Occurs Predominantly in Complex with 1-Antichymotrypsin. Clin Chem 1991;37:1618 –25. Prostate-specific antigen (PSA), a kallikrein-like serine protease, is one of the most abundant proteins secreted by the prostate into seminal fluid (1 ). In the early 1990s, when the study reported in the paper prese...

Docetaxel-based chemotherapy remains the first-line treatment for patients with metastatic castration-resistant prostate cancer (mCRPC) in China; however, the prognostic factors associated with effects in these patients are still controversial. In this study, we retrospectively reviewed the data from 71 eligible Chinese patients who received docetaxel chemotherapy from 2009 to 2016 in our hospi...

OBJECTIVE To assess the cost-effectiveness of two diagnostic strategies for prostate cancer in men with prostate-specific antigen (PSA) levels of 4-10 ng/ml and normal digital rectal examination (DRE). DESIGN Cost-effectiveness analysis was performed using a decision tree model. Data collection and a systematic review of patients at the Urology Department (Carlos Haya Hospital) were made. 101...

OBJECTIVE To determine whether higher intensity of prostate-specific antigen (PSA) surveillance was associated with earlier detection of biochemical recurrence (BCR) or survival. PATIENTS AND METHODS We identified a population-based cohort of 832 men diagnosed with nonmetastatic prostate cancer between January 1, 1995, and July 31, 2006. These men were treated with radical prostatectomy (RP),...

BACKGROUND Free and total human kallikrein 2 (hK2) might improve the discrimination between prostate cancer and benign prostatic hyperplasia. Concentrations of hK2 are 100-fold lower than concentrations of prostate-specific antigen (PSA); therefore, an hK2 assay must have a low detection limit and good specificity. METHODS PSA- and hK2-specific monoclonal antibodies were used in solid-phase, ...

PURPOSE We evaluated the association of preoperative serum cell-free circulating DNA concentration in men with clinically localized prostate cancer who underwent radical prostatectomy with prostate-specific antigen (PSA) recurrence. EXPERIMENTAL DESIGN One hundred and ninety-two men with clinically localized prostate cancer, who underwent radical prostatectomy at the Johns Hopkins Hospital an...

PURPOSE To evaluate the influence of prostate-specific antigen (PSA) kinetics following maximal androgen blockade (MAB) on disease progression and cancer-specific survival in patients with metastatic, hormone-sensitive prostate cancer. MATERIALS AND METHODS One hundred thirty-one patients with metastatic, hormone-sensitive prostate cancer treated with MAB at our institution were included in t...

BACKGROUND The relationship between prostate-specific antigen (PSA)-defined recurrence and prostate cancer-specific mortality remains unclear. Therefore, we evaluated the hypothesis that a short post-treatment PSA doubling time (PSA-DT) after radiation therapy is a surrogate end point for prostate cancer-specific mortality by analyzing two multi-institutional databases. METHODS Baseline, trea...

It is crucial to have early detection of prostate cancer as it the third most common in men and Prostate Specific Antigen (PSA) a protein-based biomarker commonly used achieve purpose. Besides, ISFET integrated with nanostructures such nanowire nanosphere has been focus research for disease diagnosis. Simulations are carried out Biosensor Lab investigate performance planar, structures detecting...