BACKGROUND Low-risk prostate cancer (PCa) patients have excellent outcomes, with treatment modality often selected by perceived effects on quality of life. Acute urinary symptoms are common during external beam radiotherapy (EBRT), while chronic symptoms have been linked to urethral dose. Since most low-risk PCa occurs in the peripheral zone (PZ), we hypothesized that EBRT using urethral sparin...

PURPOSE Although the perception exists that biochemical outcome in patients with a Gleason score of 7 with dominant pattern 4 histology is inferior to that of patients with a Gleason score of 7 with a primary Gleason grade of 3, conflicting conclusions have been reported for radical prostatectomy and brachytherapy. In this study, we evaluate the effect of the dominant histologic pattern in Glea...

During obstructive sleep apnea (OSA), systemic (Psa) and pulmonary (Ppa) arterial pressures acutely increase after apnea termination, whereas left and right ventricular stroke volumes (SV) reach a nadir. In a canine model (n = 6), we examined the effects of arousal, parasympathetic blockade (atropine 1 mg/kg iv), and sleep state on cardiovascular responses to OSA. In the absence of arousal, SV ...

BACKGROUND The present study investigated the long-term outcome of patients with localized high-risk prostate cancer after definitive conformal radiotherapy. PATIENTS AND METHODS Ninety-one consecutive patients with stage T1-T4 prostatic carcinoma were treated from 1996 through 2000. Each patient had at least one of the following risk factors: stage > T2b (UICC 1997; 55 patients), Gleason sco...

Objective: The accurate definition of what constitutes treatment failure after surgery and radiotherapy for localised prostate cancer is critical to patient management. The current post-radiotherapy (post-RT) standard is the 2006 ASTRO definition of an increase of 2 ng/ml above the nadir level. After radical prostatectomy (RP) one definition is the detection of prostate-specific antigen (PSA) a...

PURPOSE/OBJECTIVE(S) To report outcomes and toxicity for patients with oligometastatic (≤5 lesions) prostate cancer (PCa) treated with stereotactic body radiation therapy (SBRT). MATERIALS/METHODS Seventeen men with 21 PCa lesions were treated with SBRT between February 2009 and November 2011. All patients had a detectable prostate-specific antigen (PSA) at the time of SBRT, and 11 patients (...

Abstract Background Prostate cancer is most often diagnosed at the metastatic stage in many sub-Saharan African countries. The objective of our study to analyze management prostatic adenocarcinoma based on epidemiological, clinical, therapeutic and evolutionary aspects developing country context. Methods Retrospective collecting 276 patients from January 1st, 2012 December 31st, 2019 Aristide L...

PURPOSE To determine whether concurrent androgen deprivation therapy (ADT) during salvage radiotherapy (RT) improves prostate cancer treatment outcomes. METHODS AND MATERIALS A total of 630 postprostatectomy patients were retrospectively identified who were treated with three-dimensional conformal RT. Of these, 441 were found to be treated for salvage indications. Biochemical failure was defi...

AIM To present preliminary results on health-related quality of life (QoL), prostate-associated symptoms and therapeutic effects of targeted-cryosurgical ablation of the prostate (TCSAP) with androgen deprivation therapy (ADT) in high-risk prostate cancer (PCa) patients. METHODS Thirty-four men with high-risk PCa features underwent TCSAP, and ADT was added to improve the treatment outcomes. H...

Antiandrogen withdrawal syndrome (AWS) is a well-established phenomenon in prostate cancer treated with combined androgen blockade (CAB). AWS is generally defined as subjective and/or objective improvement following discontinuation of an antiandrogen. However, the duration of the AWS response is usually limited. In addition, a complete response is quite rare. We herein present the case of a pat...