Swietach, Pawel, and Richard D. Vaughan-Jones. Novel method for measuring junctional proton permeation in isolated ventricular myocyte cell pairs. Am J Physiol Heart Circ Physiol 287: H2352– H2363, 2004. First published July 8, 2004; doi:10.1152/ajpheart.00528. 2004.—Partial exposure of single ventricular myocytes to membranepermeant weak acids or bases, using a dual-microperfusion technique, g...

BACKGROUND Several studies have explored cervical kyphosis (CK) in adolescent idiopathic scoliosis (AIS) patients. However, few studies have evaluated the cervical alignment in these patients according to their coronal curve type. The aim of this study was to analyze the radiological features of cervical sagittal alignment in Lenke 1 AIS patients before and after surgery. METHODS This is a re...

Abstract BACKGROUND CONTEXT Adult spinal deformity patients treated operatively by long-segment instrumented fusion are prone to develop proximal junctional kyphosis (PJK) and failure (PJF). A gradual transition in range of motion (ROM) at the end instrumentation may reduce incidence PJK PJF, however, previously evaluated techniques have not directly been compared. PURPOSE To determine biomecha...

INTRODUCTION Although much attention has been given to the global three-dimensional aspect of adolescent idiopathic scoliosis (AIS), the accurate three-dimensional morphology of the primary and compensatory curves, as well as the intervening junctional segments, in the scoliotic spine has not been described before. METHODS A unique series of 77 AIS patients with high-resolution CT scans of th...

BACKGROUND Surgical treatments for early onset scoliosis (EOS), including growing rod constructs, involve many complications. Some are due to biomechanical factors. A construct that is more flexible than current instrumentation systems may reduce complications. The purpose of this preliminary study was to determine spine range of motion (ROM) after implantation of simulated growing rod construc...

An increase of the physiological kyphosis during growth is defined hyperkyphosis (HK) and, according to the level where the apex of the curve can be retrieved, we can distinguish a thoracic HK and a thoraco-lumbar one, also called junctional kyphosis. Since these conditions can cause pain and esthetics impairments, lead in adulthood to an higher incidence of spinal and shoulder pain, and evolve...

STUDY DESIGN Retrospective study. PURPOSE To review the results and proximal adjacent problems of long fusion (more than 4 levels) according to the level of proximal fusion (L2~T9) in adult lumbar deformity using pedicle screw fixation. OVERVIEW OF LITERATURE There are few written reports concerning proximal adjacent segmental failure according to the level of proximal fusion in adult lumba...

Gap junctional plaques were found between androgen-sensitive motoneurons of the spinal nucleus of the bulbocavernosus (SNB), using thin-section and freeze-fracture techniques. The somata and proximal dendrites of SNB motoneurons were studied after retrograde labeling with cholera toxin conjugated to HRP. Of the gap junctions observed, 45% were somatodendritic, 35% were dendrodendritic, and 20% ...

Partial exposure of single ventricular myocytes to membrane-permeant weak acids or bases, using a dual-microperfusion technique, generates large and stable intracellular pH (pHi) gradients. In this study, we have investigated the feasibility of using the technique to estimate junctional proton permeability. This was done by recording the pHi gradient developed across the junctional region of a ...

Two patients who presented by scalar ECG with an A-V junctional tachycardia were demonstrated during an electrophysiologic evaluation to have an atrial tachycardia without P waves in the surface ECG. Case 1 had an atrial tachycardia that conducted through the A-V node with a Wenckebach block. Atrial activity was recorded only from the proximal portion of the coronary sinus and from right atrial...