The authors describe a case in which injectable medroxyprogesterone failed to prevent conception and then briefly review the literature on in utero exposure to medroxyprogesterone. A 20-year-old woman presented 6 weeks after the delivery of her first child for a routine examination and expressed interest in receiving medroxyprogesterone injections. She had no contraindication to her use of su...

Lynch syndrome is one of the most common hereditary cancer syndromes. Although Lynch syndrome is associated with increased risk for developing colorectal, endometrial, and other cancers specialized screening, risk-reducing surgery, and chemoprevention offer promise for reducing morbidity and mortality. Frequent colonoscopic surveillance has proven effective for early detection and prevention of...

Objective: The purpose of this study was to understand how Canadian Obstetricians/Gynaecologists (OBGYNs) diagnose and manage adenomyosis. Methods: This cross-sectional performed via an online survey distributed 262 OBGYNs at three universities (University Toronto, University Calgary, McMaster University). Results: A total 137 responses were obtained out (52.3%) with a completion rate 98%. Aden...

MicroRNA-200c (miR-200c) through repression of specific target genes has been associated with cellular transition, tumorigenesis, and tissue fibrosis. We explored the expression and functional aspects of miR-200c in genesis of leiomyomas (LYO), benign uterine tumors with fibrotic characteristic. Using LYO and matched myometrium (MYO; n=76) from untreated and from patients exposed to hormonal th...

TO THE EDITOR—In a recent review article on sex differences, published in a supplement to The Journal of Infectious Diseases, Muenchhoff and Goulder summarized the evidence for sex differences in pediatric infectious diseases. They explain the T-helper type 1 (Th1) dominance in females [1]. It is well known that interferon γ (IFN-γ) expression is enhanced by estrogen [2]. They then mention the ...

POSTPARTUM CONTRACEPTION AND RAPID REPEAT PREGNANCIES IN RURAL, LOW-INCOME BLACK WOMEN WITH BASELINE RISK FACTOR COMPARISONS By KAREN LI July 27, 2015 INTRODUCTION: The residents in the Low Country region of South Carolina consist of a predominantly low-income, African American population with a history of trauma and experiences of racism. Chronic conditions, unintended pregnancies, and adverse...

A 16-year-old previously healthy white female presented to our office with complaints of a 1-year history of chronic severe pelvic pain, leg pain, and severe daily headaches that were adversely affecting her school performance. Her leg and pelvic pain caused weakness and discomfort to the point that she used a walker or a wheelchair when she had to ambulate distances longer than 20 feet. She ha...

Neurosteroids typified by 5alpha-pregnan-3alpha-ol-20-one (5alpha3alpha) have emerged as the most potent endogenous positive modulators of the GABAA receptor, the principal mediator of fast inhibitory transmission within the CNS. Neurosteroids can be synthesized de novo in the brain in levels sufficient to modulate GABA(A) receptor function and, thus, might play an important physiological-patho...