In proton therapy, Positron Emission Tomography (PET) range verification relies on the comparison of measured and estimated activity distributions from β + emitters produced by beam in patient. The accuracy is basically that underlying reaction cross section data. this context, we have developed a new method for measuring production yields combining multi-foil technique with clinical PET scanne...

introduction proton therapy is used to treat malignant tumors such as melanoma inside the eye. proton particles are adjusted according to various parameters such as tumor size and position and patient’s distance from the proton source. the purpose of this study was to assess absorbed doses in eyes and various tumors found in the area of sclera and choroid and the adjacent tissues in radiotherap...

OBJECTIVE Proton therapy can result in clinically significant radiation dermatitis. In some clinical scenarios, such as lung or breast cancer, the risk of severe radiation dermatitis may limit beam arrangement and prescription doses. Patients undergoing proton therapy for prostate cancer commonly develop mild radiation dermatitis. Herein, we report the outcomes of two prostate cancer patients w...

Proton therapy as one of the radiotherapy applications, aims to treat tumor by using accelerated proton particle. High radiation dose distributions delivered tissue, is characterized with Bragg curves, while in tissues surrounding expected be low possible. In our study, treatment volume placed brain created GATE software was simulated. The absorbed doses other organs during were determined Dose...

The purpose of this project is to investigate the advantages in dose distribution and delivery of proton beams focused by a triplet of quadrupole magnets in the context of potential radiosurgery treatments. Monte Carlo simulations were performed using various configurations of three quadrupole magnets located immediately upstream of a water phantom. Magnet parameters were selected to match what...

PURPOSE The physical and potential biological advantages of proton and carbon ions have not been fully exploited in radiation therapy for the treatment of cancer. In this work, an approach to predict proton and carbon ion relative biological effectiveness (RBE) in a representative spread-out Bragg peak (SOBP) is derived using the repair-misrepair-fixation (RMF) model. METHODS AND MATERIALS Fo...

BACKGROUND Considering that HTB140 melanoma cells have shown a poor response to either protons or alkylating agents, the effects of a combined use of these agents have been analysed. METHODS Cells were irradiated in the middle of the therapeutic 62 MeV proton spread out Bragg peak (SOBP). Irradiation doses were 12 or 16 Gy and are those frequently used in proton therapy. Four days after irrad...

Determination of the Bragg peak position in proton therapy requires accurate knowledge of the electron density and ratio of effective atomic number and mass (Z/A) of the body tissues traversed. While the Z/A ratio is fairly constant for human tissues, the density of tissues varies significantly. One possibility to obtain accurate electron density information of tissues is to use protons of suff...

Proton range monitoring may facilitate online adaptive proton therapy and improve treatment outcomes. Imaging of proton-induced prompt gamma (PG) rays using a knife-edge slit collimator is currently under investigation as a potential tool for real-time proton range monitoring. A major challenge in collimated PG imaging is the suppression of neutron-induced background counts. In this work, we pr...