Background: To determine mean prothrombin time and activated partial thromboplastin time in patients of end stage renal disease having normal baseline coagulation parameters after hemodialysis. Methods: In this cross sectional study 84 patients ,16-70 years of age, with end stage renal disease were selected. Prothrombin Time (PT) and Activated Partial Thromboplastin Time (APTT) were performed p...

During the process of normal blood coagulation prothrombin is converted into thrombin. As a result serum contains considerably less prothrombin than the plasma from which it is derived, the prothrombin having been consumed during the coagulation of the blood. In certain conditions this conversion is incomplete and much prothrombin remains in the serum. Often this is not obvious from the usual t...

Mannan-binding lectin-associated serine protease-1 (MASP-1), a protein of the complement lectin pathway, resembles thrombin in terms of structural features and substrate specificity. Due to its interplay with several coagulation factors, it has the ability to induce fibrin clot formation independent of the usual coagulation activation pathways. We have recently shown that MASP-1 activates proth...

Attention has recently been focused on the consumption of prothrombin during blood coagulation. Studies of the velocity of prothrombin conversion to thrombin have yielded important information concerning the clotting defect in various hemorrhagic disorders. Thrombin evolution is retarded in the coagulation of hemophilic blood (1-5), thrombocytopenic blood (3, 4, 6, 7) and blood exposed to silic...

Background: Both extrinsic as well intrinsic coagulation cascade are involved in the pathogenesis of Chronic spontaneous urticaria. This study was done to correlate disease activity and markers patients CSU. Methods: A hospital-based, cross-sectional, descriptive carried out 100 chronic Baseline D-Dimer, prothrombin time, activated partial thromboplastin time performed. Disease assessed using U...

Mannan-binding lectin-associated serine protease-1 (MASP-1), a protein of the complement lectin pathway, resembles thrombin in terms of structural features and substrate specificity, and it has been shown to activate coagulation factors. Here we studied the effects of MASP-1 on clot formation in whole blood (WB) and platelet-poor plasma (PPP) by thrombelastography and further elucidated the und...

BACKGROUND AND PURPOSE Rivaroxaban has recently been approved for stroke prevention in atrial fibrillation. However, lack of an effective antidote represents a major concern in the event of intracerebral hemorrhage (ICH). The aims of the present study were to establish a murine model of ICH associated with rivaroxaban, and to examine the effectiveness of different hemostatic factors in preventi...

OBJECTIVE Individuals with elevated prothrombin, including those with the prothrombin G20210A mutation, have increased risk of venous thrombosis. Although these individuals do not have increased circulating prothrombotic biomarkers, their plasma demonstrates increased tissue factor-dependent thrombin generation in vitro. The objectives of this study were to determine the pathological role of el...

Purified prothrombin can be converted into thrombin in different ways (2), namely, by the use of biological activators, by the action of high concentrations of sodium citrate, and by treatment with trypsin. Biological activation of prothrombin requires lipoprotein tissue-factor(s) that have prothrombin-converting or thromboplastic activity, protein serum-factor(s) which augment thromboplastic a...