Understanding mechanisms of protein flexibility is of great importance to structural biology. The ability to detect similarities between proteins and their patterns is vital in discovering new information about unknown protein functions. A Distance Constraint Model (DCM) provides a means to generate a variety of flexibility measures based on a given protein structure. Although information about...

Protein structures are valuable tools for understanding protein function. However, protein dynamics is also considered a key element in protein function. Therefore, in addition to structural analysis, fully understanding protein function at the molecular level now requires accounting for flexibility. However, experimental techniques that produce both types of information simultaneously are stil...

While it is known that protein flexibility plays a significant role in protein folding, protein-ligand interactions, catalysis, and molecular recognition, only a few techniques are capable of quantifying immunoglobulin flexibility while less is known about immunoglobulin motions. Floppy Inclusion and Rigid Substructure Topography (FIRST) can be used to measure protein flexibility and this techn...

The interest in the influence of videogame experience on our daily life is constantly growing. "First Person Shooter" (FPS) games require players to develop a flexible mindset to rapidly react to fast moving visual and auditory stimuli, and to switch back and forth between different subtasks. This study investigated whether and to which degree experience with such videogames generalizes to othe...

While brain research shows great potential for advancing critical national security interests, the products of the laboratory cannot be realized in operational practice without the polishing and maturing demanded by federal science and technology (S&T) acquisition processes, particularly those of the Department of Defense. Although many acquisition planning functions are relatively conventional...

A s the “baby boomers” approach and enter their retirement years, the accumulation phase of their life-cycle is nearly over. Thus, the focus of many researchers, fi nancial services fi rms, and public policymakers concerned with retirement saving is shifting from the accumulation of resources while working to the drawdown of resources during retirement. Retired households are dependent on the a...

Cognitive flexibility reflects both a trait that reliably differs between individuals and a state that can fluctuate moment-to-moment. Whether individuals can undergo persistent changes in cognitive flexibility as a result of reward learning is less understood. Here, we investigated whether reinforcing a periodic shift in an object selection strategy can make an individual more prone to switch ...

One of the major problems in computational drug design is incorporation of the intrinsic flexibility of protein binding sites. This is particularly crucial in ligand binding events, when induced fit can lead to protein structure rearrangements. As a consequence of the huge conformational space available to protein structures, receptor flexibility is rarely considered in ligand design procedures...

interaction of drugs with serum albumin, the most abundant protein in plasma, has a great significance in pharmaceutical sciences. it can affect the biological activity, toxicity, and pharmacokinetics of drugs and design of dosages. determination of the impact of chemical modifications of albumin and its structural changes upon interaction with drugs are very important when drugs bind with albu...