Objective(s): The rotavirus nonstructural protein 4 (NSP4) is responsible for the increase in cytoplasmic calcium concentration through a phospholipase C-dependent and phospholipase C-independent pathways in infected cells. It is shown that increasing of intracellular calcium concentration in rotavirus infected cells is associated with the activation of some members of protein kinases family su...

autoclave d dry gr ound beans and ethanol ext r acted g round beans which con t a i n t wo-thi r d of t he haemagglutinin , and one-quarter o f the t rypsin i nhibitors with 80% o f its origi nal t annin we re f ed t o rat s for determinati on the nitr ogen digestibi l i ty . the toxic f act or s of bea n s k i l led all the a nimals be fore t he complet ion o f t he 10- day per iod ass ay . fe...

background: staphylococcus aureus (s. aureus) is a major nosocomial pathogen and the infection with this organism in human is increasing due to the spread of antibiotic resistant strains. one of the resistance mechanisms of s. aureus comprises modification in binding proteins to penicillin. vaccine strategy may be useful in controlling the infections induced by this organism. this study aimed a...

Objective(s): Breast cancer is one of the most common cancers in the world and is on the increase. MUC1 and HER2 as tumor-associated antigens (TAAs) are abnormally expressed to some extent in 75–80% of breast cancers.  In our present research, a novel chimeric MUC1-HER2 (HM) protein was designed and used to study whether an immune response can be generated against these TAAs. In vitro analysis ...

abstract introduction: diabetes is one of the most common endocrine diseases spreading rapidly in the world. diabetes complications are classified into acute and chronic. non-enzymatic glycosylation of body proteins such as hemoglobin and albumin is the main cause of pathogenesis in chronic complications of diabetes. protein glycosylation is an oxidative reaction. antioxidants such as vitamin c...

Background: Nowadays, it is needed to explore new routes to treat infectious bacterial pathogens due to prevalence of antibiotic-resistant bacteria. Antimicrobial photothermal therapy (PTT), as a new strategy, eradicates pathogenic bacteria.Objective: In this study, the antimicrobial effects of a carbon nanoparticles-polypyrrole nanocomposite (C-PPy) upon laser irradiation were investigat...

Human serum albumin (HSA) is an abundant, multifunctional and nonglycosylated negatively charged plasma protein. HSA ascribed ligand-binding and transport properties, antioxidant functions and enzymatic activities. In the present study, the interaction and side effects of a new designed anti-cancer compound (1,10-phenanthroline butyl dithiocarbamato palladium(II) nitrate) on HSA have been inves...

an increase in c-reactive protein inflammatory indicator and lipid profile is accompanied with an increase in cardiovascular risks. however, the effect of resistance exercises on these cardiovascular risk factors in females is unknown.the aim of this study was to examine the effect of 12 weeks of circuit exercise on c-reactive protein and lipid profile in inactive women.for this purpose, 24 you...