نتایج جستجو برای: protected α
تعداد نتایج: 218898 فیلتر نتایج به سال:
α-Chiral amines are of significant importance in medicinal chemistry, asymmetric synthesis and material science, but methods for their efficient synthesis are scarce. In particular, the synthesis of α-chiral amines with the challenging tetrasubstituted carbon stereocentre is a long-standing problem and catalytic asymmetric additions of organometallic reagents to ketimines that would give direct...
The synthesis of spirocyclic amide acetals (33–93 %) has been achieved through Ru(II)-catalyzed condensations N-carbamate protected pyrrolidinones with metal carbenes derived from α-diazo-β-ketoesters. Thanks to the mildness diazo decomposition conditions induced by a 1 : combination [CpRu(MeCN)3][BArF] and 1,10-phenanthroline, formation sensitive products is possible. Full characterization thi...
objective(s): chlorpyrifos (cp) is a broad-spectrum organophosphorus pesticide used extensively in agricultural and domestic pest control, accounting for 50% of the global insecticidal use. in the present study, protective effects of two selenium-enriched strong antioxidative medicines imod and angipars were examined in human lymphocytes treated with cp in vitro. materials and methods: isolate...
The aim of this study was to evaluate the protective effects of different concentrations of vitamin E alpha-tocopherol (α-T) isomer against the toxicity of hydrogen peroxide (H2O2) on dental pulp cells. The cells (MDPC-23) were seeded in 96-well plates for 72 hours, followed by treatment with 1, 3, 5, or 10 mM α-T for 60 minutes. They were then exposed or not to H2O2 for 30 minutes. In positive...
Glutamate excitotoxicity is a common pathology to blinding ischemic retinopathies, such as diabetic retinopathy, glaucoma, and central retinal vein or artery occlusion. The development of an effective interventional modality to glutamate excitotoxicity is hence important to preventing blindness. Herein we showed that α-melanocyte-stimulating hormone (α-MSH) time-dependently protected against gl...
α-Synuclein can be degraded by both the ubiquitin-proteasomal system and the chaperone-lysosomal system. However, the switching mechanism between the two pathways is not clearly understood. In our study, we investigated the mutual association between the binding of α-synuclein to heat shock cognate 70 and the lysosomal translocation of α-synuclein. Tyrosine phosphorylation of Y136 on α-synuclei...
Atsttrin, an engineered molecule composed of three fragments of progranulin(PGRN), exerts comparable anti-inflammation ability. Intervertebral disc degeneration (IDD) is involved in inflammation in which TNF-α plays a key role. This study aims to examine the effect and the mechanism of Atsttrin in the pathogenesis of intervertebral disc degeneration. For this purpose, we took advantage of murin...
Dena Biosphere Reserve located in Iran and is a 550 Biosphere Reserve in the worlds. This research was investigated in the two protected and non-protected areas, in a Dena Biosphere Reserve, Kohkeloye va Boyrahmad province, and central zagros forest, southwest of Iran. Inventory methods designed by systemetic-randomaiz method by use the rectangular plots that were 15×30 meters in the 100×100 m ...
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