نتایج جستجو برای: protease inhibitor
تعداد نتایج: 245560 فیلتر نتایج به سال:
Protease inhibitors decrease the viral load in HIV patients, however the patients develop hypertriglyceridemia, hypercholesterolemia, and atherosclerosis. It has been assumed that protease inhibitor-dependent increases in atherosclerosis are secondary to the dyslipidemia. Incubation of THP-1 cells or human PBMCs with protease inhibitors caused upregulation of CD36 and the accumulation of choles...
A computational study of the two possible inhibition mechanisms rhodesain cysteine protease by dipeptidyl enoate Cbz-Phe-Leu-CH=CH−CO2C2H5 has been carried out means molecular dynamics simulations with hybrid QM/MM potentials. The low free energy barriers confirm that Cys25 residue can attack both Cβ and C1 atoms inhibitor, confirming a dual mode action in enoates. According to results, process...
With the introduction of highly active antiretroviral therapy, a number of drugs have been developed. The best choice concerning which antiretroviral analogs to start is always under discussion, especially in the choice between non-nucleoside reverse transcriptase inhibitors-based therapies and ritonavir-boosted protease inhibitors. Both are proven to control viral replication and lead to immun...
Recently a new virus strain designated as SARS coronavirus result in fatal pandemic known COVID-19. Bioinformatics and drug screening are directed for the assessment of potential inhibitors before their clinical implementation treatment this pneumonia. One expected natural potent is Portulaca oleracea which has been assigned an effective to different human ailments throughout whole world. P. wi...
A real-time fluorescence turn-on strategy for protease activity and inhibitor screening has been developed. A negatively charged benzo[ghi]perylene derivative (probe 1) was employed. Protamine is a cationic protein which can induce aggregation of probe 1 via strong electrostatic and hydrophobic interactions. The fluorescence of probe 1 was efficiently quenched. In the presence of a protease, pr...
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