We report the case of a 63-year-old male who presented with painless gross hematuria and urinary retention. Pathology obtained from transurethral resection of the prostate revealed pure small cell carcinoma of the prostate. Metastatic evaluation confirmed stage IV disease with lymphatic and hepatic metastasis. Despite aggressive systemic chemotherapy, the patient succumbed to his disease eleven...

BACKGROUND Prostatic neuroendocrine carcinomas comprise <1% of all prostate neoplasms, and approximately 200 cases have been reported in the literature. We undertook this study to describe the experience in the management of prostatic neuroendocrine carcinoma with androgen-deprivation therapy (ADT). METHODS We designed a retrospective, descriptive and observational study. In patients with sus...

Toll-like receptors are key players in initiation of innate immune response of the host. In addition to innate immunity they can also induce adaptive immune responses. The concept that inflammation can promote chronic prostatic diseases, such as benign prostatic hyperplasia or prostate carcinoma is supported by several new findings. Epidemiological data have correlated prostatitis with an incre...

Abstract There is an unexplained male predominance in the incidence of esophageal (EAC) and non-cardia gastric adenocarcinoma (GAC) which cannot be explained by known risk factors. Differences exposures to sex hormones may play a part observed difference. This study aimed test hypothesis that androgens increase EAC, cardia GAC, GAC. We analysed matched cohort based on national Swedish database ...

The human retrovirus XMRV (xenotropic murine leukemia virus-related virus) is associated with prostate cancer, most frequently in humans with a defect in the antiviral defense protein RNase L, suggesting a role for XMRV in prostate carcinogenesis. However, XMRV has not been found in prostate carcinoma cells. Here we show that 22Rv1 prostate carcinoma cells produce high-titer virus that is nearl...

Renal-type clear cell carcinoma of the prostate is a rare and novel tumor that has only been identified in recent years. The present study describes a lesion in the prostate of a 64-year-old male with a two-year history of urinary frequency, urgency and difficulty, who was admitted to the San Ai Tang Hospital for benign prostatic hyperplasia, and subsequently underwent transurethral resection o...

Prostate cancer is one of the most important malignancies in men. In old men the frequency of prostate cancer at necroscopy has been reported to exceed 40%. Dogs are the only large mammals other than humans with a significant incidence of spontaneous prostate cancer. Adenocarcinoma, transitional cell carcinoma and undifferentiated carcinoma are the most common histological type but the precise ...

BACKGROUND Pulmonary metastasis from prostate cancer is considered to be a late event, and patients can be treated with chemotherapy or hormonal manipulation. However, there has been only a few reports on surgical resection for pulmonary metastasis from prostate cancer. CASE PRESENTATION We present a surgical case of solitary pulmonary metastasis from prostate cancer. A 73-year-old man underw...

Submit Manuscript | http://medcraveonline.com Abbreviations: PCa: Prostate Carcinoma; CRPC: Castrationresistant Prostate Carcinoma; MMR: Mismatch Repair; ADT: Androgen-deprivation Therapy; OS: Overall Survival; NER: Nucleotide Excision Repair; BER: Base Excision Repair; HDR: Homology Directed Repair; HR: Homologous Recombination; DDR: DNA Damage Response; NHEJ: Non-homologous End Joining; SSB: ...

Abstract Background Dyslipidemia is directly related to morbidity and mortality in elderly prostate carcinoma patients. The purpose of this study was evaluate the effects androgen deprivation therapy (ADT) on lipid profile among Indian patients with locally advanced metastatic carcinoma. Methods prospective database patients, who received ADT whose data for first two years treatment available, ...