Upon recall, a memory can enter a labile state in which it requires new protein synthesis to restabilize. This two-phased reconsolidation process raises the prospect to directly target excessive fear memory as opposed to the formation of inhibitory memory following extinction training. In our previous studies, we convincingly demonstrated that 40 mg propranolol HCl administration before or afte...

The purpose of this investigation is to formulate and evaluate the antihypertensive drug propranolol hydrochloride sustained-release bilayer tablets. In formulation, one layer provides a loading dose through immediate release other maintenance for up 12 h controlled release. Different quantities polymers such as Kyron T-314, Hydroxypropyl methylcellulose- K4M, ethyl cellulose were used make bi-...

BackgroundPropranolol hydrochloride is a nonselective beta-adrenergic antagonist that has known activity in the myometrium. Small trials have shown propranolol decreases duration of induced labor, although those studies are limited by methodological variability.ObjectiveOur objective was to determine whether addition single dose induce labor nulliparous women would decrease total time vaginal d...

   The objective of the present investigation was to develop and evaluate a contraceptive vagino-adhesive propranolol hydrochloride gel. To achieve this, various mucoadhesive polymers including guar gum (1-4% w/w), sodium alginate (4-7% w/w), xanthan gum (2-5% w/w ), HPMC 4000 (3-5% w/w), Na CMC (4-7% w/w), carbomer 934 and carbomer 940 both in the range of 0.5-2.0% w/w, were dispersed in an aq...

Finding a bioactive hybrid material with the potential for controlled drug release has been one of major targets tissue engineering in recent years. In this line, present work describes new approach producing singular hydrogel microparticles (HMPs) different morphologies and compositions by combining experimental computational methods. Calcium-Alginate (Ca-ALG) core–shell Alginate-Chitosan micr...

BACKGROUND AND THE PURPOSE OF THE STUDY The purpose of the present investigation was to characterize, optimize and evaluate microballoons of Propranolol hydrochloride and to increase its boioavailability by increasing the retention time of the drug in the gastrointestinal tract. METHODS Propranolol hydrochloride-loaded microballoons were prepared by the non-aqueous O/O emulsion solvent diffus...

a mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. in this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. determination of these drugs was perf...