نتایج جستجو برای: promyelocytic leukemia
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These NCCN Guidelines Insights summarize several key updates to the NCCN Guidelines for Acute Myeloid Leukemia and discuss the clinical evidence that support the recommendations. The updates described in this article focus on the acute promyelocytic leukemia (APL) section, featuring recommendations for additional induction/consolidation regimens in patients with low- or intermediate-risk APL, a...
This session addressed acute promyelocytic leukemia (APL), multiple myeloma, and myelodysplastic syndromes. In particular, arsenic trioxide as a treatment for APL, one of the most highly curable types of acute myeloid leukemia, was discussed. Speakers also discussed the use of combination regimens in clinical trials for multiple myeloma treatments and therapeutic agents in the treatment of myel...
Chromosomal translocations in hematological malignancies often result in novel fusion chimeric genes. We report a case of acute myeloid leukemia with a clonal translocation t(11;12)(p15;q13) displaying morphologic and immunophenotypic features resembling the classical hypergranular subtype of acute promyelocytic leukemia. The gene fused to NUP98 (nucleoporin 98) was detected by comparative geno...
The therapeutic approach to the patient with acute myeloid leukemia (AML) currently evolves toward new frontiers. This is particularly apparent from the entree of high-throughput diagnostic technologies and the identification of prognostic and therapeutic targets, the introduction of therapies in genetically defined subgroups of AML, as well as the influx of investigational approaches and novel...
TO THE EDITOR: Acute leukemia during pregnancy is rare [1-8]. The exact incidence of acute promyelocytic leukemia (APL) in pregnant women is unknown; however, approximately 50 such cases have been reported in the literature [1-4, 7, 8]. APL is a unique type of acute myeloid leukemia (AML) characterized by proliferation of neoplastic promyelocytes bearing a specific chromosomal translocation t(1...
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