Background: In prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 (MRP1) by an effect on promoter region. Objectives: The objective of this study was to identify association...

Abstract BACKGROUND Thrombocytopenia represents the main cause of stopping chemotherapy for toxicity during treatment glioblastoma. Here we explored incidence and prognostic implications lomustine modification thrombocytopenia in recurrent METHODS We retrospectively analysed thrombocytopenia, its consequences delivery, associations with outcome phase II III parts EORTC 26101, a randomized trial...

AbstractAim of the study Benefit from temozolomide (TMZ) chemotherapy in treatment isocitrate dehydrogenase (IDH)–wild-type glioblastoma is essentially limited to patients with O6-methylguanine DNA methyltransferase (MGMT) promoter–methylated tumours. Recent studies suggested that telomerase reverse transcriptase (TERT) promoter hotspot mutations may h...

Inactivation of tumor suppressor genes is a frequent event in carcinogenesis. In skin cancer, the CDKN2A gene, which encodes p16INK4A and p14ARF proteins, often silenced by epigenetic abnormalities such as promoter DNA methylation histone deacetylation. The cell cycle regulator plays key role growth metastasis. Unlike gene loss, silencing aberrant modifications can be reversed small-molecule co...

The multicellular green alga Volvox carteri has emerged as a valuable model organism for investigating various aspects of multicellularity and cellular differentiation, photoreception phototaxis, cell division, biogenesis the extracellular matrix morphogenetic movements. While range molecular tools bioinformatics resources have been made available exploring these topics, establishment type-spec...

Background: Tumor necrosis factor-beta or lymphotoxin-alpha (LT-α), IL-4 and IL-10 are determining factors in immunity against BCG.  Allelic polymorphisms in the regulatory regions of their genes affect the rate of cytokine production and therefore, the host’s ability in BCG containment. Objective: To study the prevalence of –590 (C/T) and –592 (C/A) allelic distribution of IL-4 and IL-10 promo...

Objective(s): Apoptotic effect of apoptin has been demonstrated in numerous studies. However, its tumor specificity has been questioned by some reports. The aim of this study was to confine the expression of apoptin in the prostate tumor cells by inducing its gene expression under the control of a chimeric enhancer composing of prostate-specific membrane antigen (PSMA) and prostate-specific ant...

BACKGROUND: Some of metal ions as environmental pollutants show estrogenic activity. This xenostrogenic compounds can be caused carcinogenicity in organs. The mechanism of carcinogenicity of metal ions is not clarified. OBJECTIVES: In this study, we investigated the Transcriptional effects of variety of metal ions on the bovine oxytocin and the thymidine kinase-ERE promoter by estrogen receptor...