OBJECTIVE To assess the usefulness of corneal esthesiometry for screening diabetic retinopathy. METHODS A cross-sectional study was carried out comprising 575 patients attending a diabetic retinopathy-screening program in the city of São Paulo. Corneal esthesiometry was assessed with the Cochet-Bonnet esthesiometer. The presence of diabetic retinopathy was detected with indirect fundoscopy. T...

AIM To investigate and quantify changes in the branching patterns of the retina vascular network in diabetes using the fractal analysis method. METHODS This was a clinic-based prospective study of 172 participants managed at the Ophthalmological Clinic of Cluj-Napoca, Romania, between January 2012 and December 2013. A set of 172 segmented and skeletonized human retinal images, corresponding t...

BACKGROUND Folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia. This study has been undertaken to investigate the role of folate status during the progression of the diabetic retinopathy. METHODS We measured the plasma levels of homocysteine, folic acid, and red cell folate in 70 diabetic type 2 patients with nonproliferative diabet...

AIM/HYPOTHESIS The aim of our study was to characterize the human salivary proteome and determine the changes in protein expression in two different stages of diabetic retinopathy with type-2 diabetes mellitus: (1) with non-proliferative diabetic retinopathy (NPDR) and (2) with proliferative diabetic retinopathy (PDR). Type-2 diabetes mellitus without diabetic retinopathy (XDR) was designated a...

Diabetic Retinopathy (DR) was the fifth most prevalent cause of preventable blindness and thefifth common moderate to severe vision impairment between 1990 ̶̶ 2010. [1] Over one-third worlds 285 million diabetics have indications DR, a third these vision-threatening diabetic retinopathy (VTDR), which is defined as non-proliferative DR or proliferative (PDR) presence macular edema (DME)[2]. DM...

PURPOSE To study the correlation between serum levels of vitamin B12, folic acid, and homocysteine and the severity of diabetic retinopathy and the correlation with retinal nerve fiber layer (RNFL) thinning on spectral domain optical coherence tomography (SD-OCT). METHODS In a tertiary care center-based prospective cross-sectional study, 60 consecutive cases and 20 healthy controls in the age...

CONTEXT Diabetic retinopathy is fast becoming an important cause of a visual disability. The visual disability which results from diabetes is a significant public health problem; however, this morbidity is largely preventable and treatable. If it is managed with a timely intervention, the quality of life can be preserved. AIMS The objective of this study was to investigate the association of ...