objective(s): lipocalin2 (lcn2) gene is highly expressed in response to various types of cellular stresses. the precise role of lcn2 has not been fully understood yet. however, it plays a key role in controlling vital cellular processes such as proliferation, apoptosis and metabolism. recently it was shown that lcn2 decreases senescence and increases proliferation of mesenchymal stem cells (msc...

Objective: To investigate the role of KIF3C gene in promoting malignant phenotype lung cancer cells and regulating PI3K/AKT signaling pathway. Methods: CCK-8 transwell assays were used to detect changes cell proliferation migration ability after being transfected with siKIF3C, as well protein expression levels PI3K, p-PI3K, AKT, p-AKT following downregulation by Western blot. Results: The assay...

Primula auriculata (Tootia) is one of the most important local medicinal plants in Hamedan district, Iran. To investigate cytotoxicity and apoptosis induction of crude methanolic extract and different fraction of it we compared several methods on HT-29 human colon Adenocarcinoma cells. Cancer cell proliferation was measured by 3-(4, 5‑dimethylthiazolyl)-2, 5‑diphenyl‑tetrazolium bromide (MTT) a...

Objective(s): Lipocalin2 (Lcn2) gene is highly expressed in response to various types of cellular stresses. The precise role of Lcn2 has not been fully understood yet. However, it plays a key role in controlling vital cellular processes such as proliferation, apoptosis and metabolism. Recently it was shown that Lcn2 decreases senescence and increases proliferation of mesenchymal stem cells (MSC...

  Objective(s): Recent investigations show that both proliferation and secretion of macromolecules by cells can be regulated by low level laser therapy (LLLT). The aim of this study was to determine whether LLLT could induce a bio-stimulatory effects on human gingival fibroblasts (HGF3-PI 53). Therefore, the effect of laser irradiation on human gingival cell proliferation and collage...

The cytotoxic chloroform fraction of Euphorbia aellenii afforded two cycloartane type triterpenes — cycloart-25-en-3,24-diol (1) and 24-methylene-cycloartan-3-ol (2) — for the first time from this plant. Preparation of cycloartane derivatives, 3, 24-O-diacetyl-cycloart-25-en as compound 3 and 3-O-acetyl-24-methylene-cycloartan (4) were conducted by acetylating of 1 and 2, respectively. The ...

The ethyl acetate partition of dried methanolic extract of aerial parts of Euphorbia microsciadia (Euphorbiaceae) afforded three pentacyclic triterpenes, betulinic acid (1) from lupane type, oleanolic acid (2) from oleane type and ursolic acid (3) from ursane type triterpenes that are reported for the first time in this plant. These three compounds were structurally compared through their mass ...

Circular RNAs (circRNAs) play a crucial role in tumor occurrence and progression. And the dysregulated circRNAs are reported to be relevant glioma development. Nevertheless, function regulatory mechanism of hsa_circ_0030018 progression largely indistinct. The abundances hsa_circ_0030018, miR-1297, RAB21 were detected using quantitative real-time polymerase chain reaction or western blot. Cell p...

Non-healing wounds are a global health problem. Substances that enhance cell proliferation, angiogenesis, and prevention of bacterial infections accelerate the wound healing process. In this study, potential Ziziphus oenoplia, is investigated for its ability in antibacterial potential. The proliferation enhancement (mean percent closure) angiogenic response vascular index) hexanes, dichlorometh...

Introduction The aim of this study was to discuss the effects and mechanisms lncRNA in renal injury induced by diabetes vivo vitro study. Material methods Collecting healthy DN patients, measuring ANRIL expression RT-qPCR assay serum. Measuring normal, 10d 20d model rats kidney. LDH, MDA, SOD, IL-6 TNF-α concentration Elisa assay, evaluating kidney pathology HE staining, cell apoptosis TUNEL re...