Motivation and Objectives A major goal in biomedicine is to determine the underlying genetic causes of human diseases in order to better understand them and support their prevention and treatment. However, the genetic bases of many multifactorial diseases are still unclear, and high-throughput technologies typically report hundred or thousands of genes associated to a disease of interest. In th...

Colorado's adult obesity rate has more than doubled since 1995, prompting its Department of Public Health and Environment to list obesity as its top prevention priority. To initiate comprehensive and effective action, the department used a well-known evidence-based public health framework developed by Brownson and others. This article describes the tools and process developed to conduct 2 of th...

Database Management Systems (DBMS) are at the core of many modern applications, ranging from e-Commerce (e.g. Amazon.COM), web applications (e.g. flickr), online banking, telephony, and even traditional brick-and-mortar retailers. DBMS can be a significant source of delay in these applications, making DBMS the performance bottleneck: users can spend orders of magnitude more time waiting for the...

Although a healthcare system crippled by lack of resources cannot perform effectively, spending more money in an ineffective system may not lead to better outcomes. To ensure systemwide resource maximization, evidence-based medicine and guidelines that consider treatment cost-effectiveness and recommend treatment for persons with the most to gain are required. To demonstrate that increasing use...

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .

This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online at https://www.biomedcentral.com/collections/annualupdate2018 . Further information about the Annual Update in Intensive Care and Emergency Medicine is available from http://www.springer.com/series/8901 .

INTRODUCTION Inadequate access to essential medicines is a common issue within developing countries. Policy response is constrained, amongst other factors, by a dearth of in-depth country level evidence. We share here i) gaps related to access to essential medicine in Pakistan; and ii) prioritization of emerging policy and research concerns. METHODS An exploratory research was carried out usi...

BACKGROUND The prioritization of chemicals for toxicity testing is a primary goal of the U.S. Environmental Protection Agency (EPA) ToxCast™ program. Phase I of ToxCast used a battery of 467 in vitro, high-throughput screening assays to assess 309 environmental chemicals. One important mode of action leading to toxicity is endocrine disruption, and the U.S. EPA's Endocrine Disruptor Screening P...

the field of cognitive psychology has increasingly provided scientific insights to explore how humans are subject to unconscious sources of evidentiary bias, leading to errors that can affect judgement and decision-making. increasingly these insights are being applied outside the realm of individual decision-making to the collective arena of policy-making as well. a recent editorial in this jou...