نتایج جستجو برای: primary progressive ms
تعداد نتایج: 862134 فیلتر نتایج به سال:
BACKGROUND Although cigarette smokers are at increased risk of developing multiple sclerosis (MS), the effect of smoking on the progression of MS remains uncertain. OBJECTIVE To establish the relationship between cigarette smoking and progression of MS using clinical and magnetic resonance imaging outcomes DESIGN Cross-sectional survey and longitudinal follow-up for a mean of 3.29 years, en...
BACKGROUND Nitric oxide (NO) may play a role in tissue destruction and axonal degeneration in multiple sclerosis (MS). OBJECTIVE To investigate NO production by peripheral blood leukocytes (PBL) in patients with a benign and progressive course of MS. METHODS PBL were isolated from 25 patients with a benign course of MS (BMS), 33 with secondary progressive MS (SPMS), 21 with primary progress...
Multiple sclerosis (MS) is a chronic, autoimmune disease affecting the central nervous system. The disease targets the myelin sheaths around nerves, leading to inflammation, myelin loss, and axonal destruction. MS is the most common cause of neurologic disability in people between the ages of 20 and 40. There are approximately 400,000 cases of MS in North America and approximately 2.5 million w...
results when the two ms groups were compared together, we found that cr was significantly increased (p value=0.008) and naa/cr was significantly decreased (p value=0.03) in non-enhancing lesions in ppms compared with rrms. there was no significant difference in naa, cho or naa/cho between the two ms subtypes. conclusion mrs is a potential way to differentiate ppms and rrms. objectives we compar...
cognitive impairment may be a common even at the onset of multiple sclerosis (ms). in this case-control study, we tried to find out the probable relationship between homocysteine levels and cerebral atrophy or cognitive impairment in patients with multiple sclerosis. one hundred fifty six patients who had ms according to mcdonald diagnostic criteria were included in this study. patients’ age, g...
BACKGROUND Both multiple sclerosis (MS) susceptibility and MS clinical phenotype are in part genetically determined. [Alpha]B-crystallin is a candidate autoantigen in MS, and there are three polymorphisms in the promoter region of the encoding gene (CRYAB): at positions -C249G, -C650G, and -A652G. METHODS These polymorphisms were studied in sporadic cases of MS, assessing disease susceptibili...
OBJECTIVE To look for HLA class II alleles and haplotypes conferring susceptibility to multiple sclerosis (MS) in the Jewish population of Israel. DESIGN Population-based cohort of clinically definite patients with MS tested prospectively over 7 years. SETTING Referral center in a neurology clinic at a university hospital in the greater Jerusalem area in Israel. PATIENTS A total of 162 co...
Background: Multiple sclerosis (MS) is a chronic, typically progressive and most common autoimmune disease which damaged the central nervous system. According to the reports in 2008, this disorder has affected 2 and 2.5 million people globally. While the reason is not clear, proposed causes for this include immunologic, environmental, infectious and genetic factors, and sexuality. MS can cause ...
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