background: mccune albright syndrome is rare with an estimated prevalence of 1 in 100,000 to 1 in 1,000,000 persons. the classical clinical triad consists of fibrous dysplasia of the bone, café-au-lait skin spots and precocious puberty. however, in rare cases, there may be primary hypogonadism and amenorrhea. case presentation: an eighteen-year-old female presented with amenorrhea. she had a sh...

Background: Primary hypothyroidism is a common medical condition. It can lead to pituitary adenoma which is usually asymptomatic, but it can also lead to symptomatic macroadenomas which are hard to diagnose due to different clinical presentations. Case presentation: A 16-year-old girl presented for endocrinology consultation prior to neurosurgical operation. She had galactorrhea which was acco...

despite the fact that hepatic involvement is frequently seen in systemic primary amyloidosis, major hepatic symptoms as primary manifestation and severe impaired liver function are rare. herein, we report a 38-year-old woman with primary hepatic amyloidosis, and severe  portal hypertension . the patient had ascites and markedly elevated alkaline phosphatase level at presentation. she had a rapi...

Primary pancreatic lymphoma is a rare extranodal manifestation of any histopathologic subtype of B cell non-Hodgkin's lymphoma that predominantly involves the pancreas. It comprises less than 0.2% of pancreatic malignancies and less than 0.7% of non-Hodgkin's lymphomas. This lymphoma is almost never suspected clinically. It is usually diagnosed by surgical exploration for suspected adenoca...

background: angiosarcoma can develop in all parts of the body containing blood vessels, including breast. statistically, less than 10% of all angiosarcomas originate in the breast. angiosarcoma accounts for less than 0.05% of breast primary cancers. primary angiosarcoma develops without a history of treatment for breast cancer, whereas secondary angiosarcoma develops in patients who have alread...