نتایج جستجو برای: primary branching
تعداد نتایج: 668298 فیلتر نتایج به سال:
Primary clear cell renal cell carcinoma (ccRCC) genetic heterogeneity may lead to an underestimation of the mutational burden detected from a single site evaluation. We sought to characterize the extent of clonal branching involving key tumor suppressor mutations in primary ccRCC and determine if genetic heterogeneity could limit the mutation profiling from a single region assessment. Ex vivo c...
We present new links between some remarkable martingales found in the study of the Binary Search Tree or of the bisection problem, looking at them on the probability space of a continuous time binary branching process.
A curious connection exists between the theory of optimal stopping for independent random variables, and branching processes. In particular, for the branching process Zn with o spring distribution Y , there exists a random variable X such that the probability P (Zn = 0) of extinction of the nth generation in the branching process equals the value obtained by optimally stopping the sequence X1; ...
MicroRNAs (miRNAs) are ∼21-nucleotide noncoding RNAs that play critical roles in regulating plant growth and development through directing the degradation of target mRNAs. Axillary meristem activity, and hence shoot branching, is influenced by a complicated network that involves phytohormones such as auxin, cytokinin, and strigolactone. GAI, RGA, and SCR (GRAS) family members take part in a var...
Turing mechanisms can yield a large variety of patterns from noisy, homogenous initial conditions and have been proposed as patterning mechanism for many developmental processes. However, the molecular components that give rise to Turing patterns have remained elusive, and the small size of the parameter space that permits Turing patterns to emerge makes it difficult to explain how Turing patte...
The molecular mechanisms underlying the effect of thyroid hormone (T(3)) on neurite outgrowth are unknown. We recently identified the small GC-box binding protein BTEB (basic transcription element-binding protein) as a T(3)-regulated gene in the developing rat brain. BTEB mRNAs are rapidly (by 1 h) up-regulated by T(3) in primary rat embryonic neuronal cultures. Antisense oligodeoxynucleotides ...
The Kesten-Stigum Theorem is a fundamental criterion for the rate of growth of a supercritical branching process, showing that an L log L condition is decisive. In critical and subcritical cases, results of Kolmogorov and later authors give the rate of decay of the probability that the process survives at least n generations. Through a uniied approach, we give conceptual proofs of these theorem...
The lacrimal gland provides an excellent model with which to study the epithelial-mesenchymal interactions that are crucial to the process of branching morphogenesis. In the current study, we show that bone morphogenetic protein 7 (Bmp7) is expressed with a complex pattern in the developing gland and has an important role in regulating branching. In loss-of-function analyses, we find that Bmp7-...
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