نتایج جستجو برای: primary and metastatic melanoma

تعداد نتایج: 16947239  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه پیام نور - دانشگاه پیام نور استان همدان - دانشکده ادبیات و علوم انسانی 1390

abstract this study is an attempt to determine the effect of nano- technology education on science lesson for fifth grade in primary school in the city of kermanshah. this research is experimental and is conducted in the from of pre-test and post- test for the control group. an achievement test was administered to determine the rate of learning in the students. the research is an applied one. ...

2010
Markku Miettinen

Soft tissue tumors are generally defined as tumors of connective tissues, including nonosseous sarcomas, benign mesenchymal tumors, and tumor-like proliferations. These tumors are usually considered to include non-osseous tumors of the extremities, trunk wall, intraabdominal and intrathoracic space, and head and neck, although definitions vary. Generally excluded from this definition are nonmes...

Journal: :Investigative ophthalmology & visual science 2008
Wanhua Yang Peter W Chen Haochuan Li Hassan Alizadeh Jerry Y Niederkorn

PURPOSE To assess the expression of PD-L1 on human uveal melanomas and its potential to suppress T-cell function. METHODS A panel of primary and metastatic uveal melanoma cell lines was evaluated for PD-L1 expression by RT-PCR and flow cytometric analysis. Uveal melanoma-containing eyes were examined for PD-L1 expression by immunohistochemistry. PD-L1 function was tested by coculturing IFN-ga...

2016
Allison L. Isola Kevinn Eddy Suzie Chen

Cancer is the second leading cause of death in the United States, and about 6% of the estimated cancer diagnoses this year will be melanoma cases. Melanomas are derived from transformation of the pigment producing cells of the skin, melanocytes. Early stage melanoma is usually curable by surgical resection, but late stage or subsequent secondary metastatic tumors are treated with some success w...

2011
Vasilios P. Papastefanou Victoria M. L. Cohen

Uveal melanoma is the most common primary intraocular malignancy and the leading primary intraocular disease which can be fatal in adults. In this paper epidemiologic, pathogenetic, and clinical aspects of uveal melanoma are discussed. Despite the advance in local ocular treatments, there has been no change in patient survival for three decades. Development of metastases affects prognosis signi...

Journal: :Lijecnicki vjesnik 2016
Davorin Herceg Daska Stulhofer Buzina Romana Ceović Snjezana Dotlić Ivana Ilić Sanda Smuđ Orehovec Gordana Horvatić Herceg Davor Mijatović Robert Separović Tajana Silovski Damir Vrbanec

Melanoma in the Western world has an increasing incidence. One of the most important factor for the increase in incidence is sporadic, uncontrolled exposure to the sun. The basis for the treatment of primary melanoma is surgical treatment. Treatment of metastatic disease of melanoma in recent years experienced significant changes. BRAF and MEK inhibitors, immunotherapy with programmed cell-deat...

Journal: :International journal of clinical and experimental pathology 2015
Zhuo-Ping Liang Sheng-En Xu Liang Jiang Chong Zhao Xiao-Qiang Sun Gang Qin

Parotid malignancy may occur as a primary neoplasm of the salivary tissue or as metastatic involvement of the parotid lymph nodes. Primary tumors of squamous cell carcinoma and malignant melanoma involving the skin of the head and neck have the potential to spread to lymph nodes of the parotid gland. Metastatic malignant melanoma to the back was exceptionally rare and no such reports have been ...

Objective(s): Growing evidences have indicated microRNAs as modulators of tumor development and aggression. On the other hand, a phenomenon known as epithelial-mesenchymal transition (EMT) that indicates a transient phase from epithelial-like features to mesenchymal phenotype is a key player in tumor progression.  In this study, we aimed to assess the potential impacts...

2015
Charlotte Welinder Krzysztof Pawłowski Yutaka Sugihara Maria Yakovleva Göran Jönsson Christian Ingvar Lotta Lundgren Bo Baldetorp Håkan Olsson Melinda Rezeli Bo Jansson Thomas Laurell Thomas Fehniger Balazs Döme Johan Malm Elisabet Wieslander Toshihide Nishimura György Marko-Varga

Malignant melanoma has the highest increase of incidence of malignancies in the western world. In early stages, front line therapy is surgical excision of the primary tumor. Metastatic disease has very limited possibilities for cure. Recently, several protein kinase inhibitors and immune modifiers have shown promising clinical results but drug resistance in metastasized melanoma remains a major...

2012
Alexander M. Menzies Lauren E. Haydu Lydia Visintin Matteo S. Carlino Julie R. Howle John F. Thompson Richard F. Kefford Richard A. Scolyer Georgina V. Long

Purpose:Certain clinicopathologic features correlate with BRAFmutation status inmelanoma including younger age and primary subtype. This study sought to determine the BRAFmutation status by age-decade and whether BRAF-mutant genotypes correlated with clinicopathologic features and outcome in patients with metastatic melanoma. Methods: A prospectively assembled cohort of Australian patients were...

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