This paper describes an automated approach to handling Big Data workloads on HPC systems. We describe a solution that dynamically creates a unified cluster based on YARN in an HPC Environment, without the need to configure and allocate a dedicated Hadoop cluster. The end user can choose to write the solution in any combination of supported frameworks, a solution that scales seamlessly from a fe...

In this paper, we describe a trilogy of Massive Open Online Courses (MOOCs) that together expose knowledge and skills of fundamental importance to HPC. Linear Algebra: Foundations to Frontiers (LAFF) covers topics found in an introductory undergraduate course on linear algebra. It links abstraction in mathematics to abstraction in programming, with many enrichments that connect to HPC. LAFFOn P...

Virtualization has gained increasing attention in the recent High Performance Computing (HPC) development. While HPC provides scalability and computing performance, HPC in the cloud benefits in addition from the agility and flexibility that virtualization brings. One of the major challenges of HPC in virtualized environments is RDMA virtualization. Existing implementations of RDMA virtualizatio...

The hippocampal formation (HPC) and medial prefrontal cortex (mPFC) have well-established roles in memory encoding and retrieval. However, the mechanisms underlying interactions between the HPC and mPFC in achieving these functions is not fully understood. Considerable research supports the idea that a direct pathway from the HPC and subiculum to the mPFC is critically involved in cognitive and...

Although unusual, hemangiopericytoma (HPC) can be considered benign or malignant depending on histologic features. In some cases, malignant HPC can behave as high-grade sarcomas. When HPC is deemed malignant, radical surgical excision is the treatment of choice. Adjuvant chemotherapy and radiation therapy offer limited success in patients with this malignancy. This article details a case study ...

For nonhumans, it has been shown that the hippocampus (HPC) is critical for spatial memory. We tested patients with unilateral HPC resections on a virtual analogue of a classic spatial task to assess HPC functioning in nonhumans: the Morris water task. We found that when humans are required to use spatial cues to navigate to a hidden escape platform in a pool, patients with HPC resections displ...

The hippocampus (HPC) may be functionally heterogeneous in supporting spatial learning in rats. Thus, dorsal but not ventral HPC lesions have been reported to impair acquisition in the Morris water task which consists of finding a submerged platform in a pool filled with opaque water. To further investigate the functional differences between dorsal and ventral HPC regions, we used a one-trial m...

High-performance computing (HPC) has become a state strategic technology in a number of countries. One hypothesis is that HPC can accelerate biopharmaceutical innovation. Our experimental data demonstrate that HPC can significantly accelerate biopharmaceutical innovation by employing molecular dynamics-based virtual screening (MDVS). Without using HPC, MDVS for a 10K compound library with tens ...