Sales of low-calorie sweeteners are increasing in the Unites States, with sucralose representing second largest U.S. market share. Since >99% ingested is excreted as parent compound, it represents a contaminant emerging concern and has been proposed an indicator pollution natural waters by anthropogenic waste. Many report that increasingly omnipresent surface, coastal, drinking water. Given ...

Reading the report ‘The Digital Future of Mental Healthcare and its Workforce’ by National Health Service (NHS) from United Kingdom makes for a strange experience. Most centrally, it is utterly perplexing that no single argument mounted in to wave aside accusations depicts totalitarian world governed digipsy-complex. As seems presage COVID crisis assertion digital mental health care will should...

The general theme of change in philosophy over time is due to traditional customs and beliefs failing to regulate society. This theme drove both John Dewey's Progressive Movement and the creation of the Curriculum and Evaluation Standards for School Mathematics (1989) by the National Council of Teachers of Mathematics (NCTM). The remarkable similarity in thought between Dewey's writings and the...

Volcan Santiaguito (Guatemala) “breathes” with extraordinary regularity as the edifice’s conduit system accumulates free gas, which periodically vents to the atmosphere. Periodic pressurization controls explosion timing, which nearly always occurs at peak inflation, as detected with tiltmeters. Tilt cycles in January 2012 reveal regular 26 ± 6min inflation/deflation cycles corresponding to at l...

The mammalian neocortex consists of a mosaic of columnar units whose development is poorly understood. Optical recordings of brain slices labeled with the fluorescent calcium indicator fura-2 revealed that the neonatal rat cortex was partitioned into distinct domains of spontaneously coactive neurons. In tangential slices, these domains were 50 to 120 micrometers in diameter; in coronal slices ...

Welcome, dear readers, to the third issue of the current 22nd volume of our journal. As I write, the heat and humidity of summer are slowly giving way the cooler nights which presage the first welcome days of autumn. The Japanese semi (cicadas) are singing away during their short but frenetic 72 hours of life above the ground, but the droning “meeee-meeee” semi of high summer is giving way to t...

Mutations in the p53 gene were detected in 58% of tumor DNAs of patients with a family history of breast cancer (FHBC) compared to 13% with sporadic breast cancer. Seven of 18 FHBC tumors contained the same G to C transversion in codon 156. Novel alleles of altered length were seen in one or more loci on chromosome 17 in 15 of 18 patients with FHBC but only in a single locus in 8 of 14 patients...