Two different approaches to the eleven-membered biaryl ether lactones of the aspercyclide family are disclosed. The core regions of these highly strained targets, which are able to interfere with the binding of immunoglobulin E to its high affinity receptor, can either be forged by ring-closing olefin metathesis (RCM) or by a highly diastereoselective chromium-mediated Nozaki-Hiyama-Kishi (NHK)...

Carbamoyl chlorides are important intermediates, both in the research laboratory and in industrial scale syntheses. The most studied and used are the disubstituted derivatives, incorporating either aryl or alkyl groups (Ar2NCOCl or R2NCOCl). Sometimes, the groups are tied back to give a ring and piperidino- and morpholino-derivatives are commonly encountered. Some studies have been made with tw...

The method of preparing protein-free filtrates by the use of tungstic acid, as developed and used by Folin, has proved so highly satisfactory in the determination of a number of blood constituents, that it has seemed desirable to apply it to the determination of chlorides. The procedure developed for this purpose is based upon the principle of the Volhard method;l namely, the precipitation of s...

Growth and development of the fetus, preparation of mammary gland for lactation, reproductive system regeneration after parturition and preparation of an organism for new fertilization and pregnancy, force adaptive changes, both morphological and functional, in pregnant and lactating cow. This may result in variations in concentration of minerals in blood. That is why it is very important to mo...

The preparation and characterisation of synthetic enzyme complexes simulating those usually encountered in soil were investigated. Complexes were prepared at 308C by the interaction of acid phosphatase and tannic acid in the presence and absence of Fe and Mn ions (as chlorides) and oxides, with and without montmorillonite. In comparison with phosphatase–tannic acid complexes, the enzymatic comp...

The aim of this work is to develop a simple, fast and efficient method for the synthesis optically pure enantiomers some 5-aryl-substituted 3-methyl‑7-nitro‑1,2-dihydro‑3H‑1,4-benzodiazepin‑2-ones using simple reagents. In course study, we found that interaction 2-amino‑5-nitrobenzophenone or 2-amino‑2’-chloro‑5-nitrobenzophenone with active L- D‑α-alanine N‑carboxyanhydrides in presence two eq...