Studies were conducted in rats to determine the effect of maternal diabetes and the consequent hyperglycemia on cardiovascular function in the offspring. Diabetes was induced in pregnant Wistar rats through streptozotocin injection (50 mg/kg). Cardiovascular parameters were measured in 2-mo-old offspring animals of diabetic (OD, n=12) and control rats (OC, n=8). Arterial pressure (AP), heart ra...

prenatal stress in rats results in structural, physiological and behavioral alterations that persist in adulthood. serotonin (5-ht) is an important neurotransmitter known to be involved in these prenatal stress-induced behavioral alterations. the aim of the study was to investigate the effects of interrupted synthesis of 5-ht and immobilization stress during different gestational period on brai...

Objective: To see the dose dependent effects of zinc chloride on the short-term and long-term memory in a shuttle box (rats). Methodology: Six pair adult wistar rats were taken for this experiment. One group of pregnant rats received a daily oral dose of 20mg/kg Zn as zinc chloride and the remaining groups received a daily oral dose of (30, 50, 70,100mg/kg) zinc chloride for two weeks by gavage...

Leptin is involved in regulating food intake, energy balance and bone formation. Increasing evidence suggests that leptin is also involved in fetal growth and development. The aim of this study was to determine if increased maternal leptin is followed by changes in body composition, skeletal growth or hormonal regulation in the adult rat offspring. Pregnant rats were given injections of either ...

Previous studies have shown that a diet high in polyunsaturated fatty acids increases mammary tumor incidence in adult and pregnant mice and rats and in the female offspring. The present study investigated whether a high-fat diet alters the number of estrogen receptor (ER) binding sites and protein kinase C (PKC) activity in the mammary gland of these animals. In the female offspring, the effec...

Despite the potential adverse effects of maternal sleep deprivation (MSD) on physiological and behavioral aspects of offspring, the mechanisms remain poorly understood. The present study was intended to investigate the roles of microglia on neurodevelopment and cognition in young offspring rats with prenatal sleep deprivation. Pregnant Wistar rats received 72 h sleep deprivation in the last tri...

Effects of environmental factors may be transmitted to the following generation, and cause neuropsychiatric disorders including depression, anxiety, posttraumatic stress disorder in offspring. Enhanced synaptic plasticity induced by enrichment also transmitted. We here test hypothesis that effects brain injury pregnant animals produce neurological deficits Unilateral (UBI) ablation hindlimb sen...