OBJECTIVE Excess adiposity may influence various aspects of pubertal development, including the timing of pubertal initiation and hormonal parameters during puberty. The aim of the study was to evaluate the impact of body mass index (BMI) on luteinizing hormone (LH) secretion to gonadotropin-releasing hormone (GnRH) stimulation test in boys with precocious puberty. METHODS Boys with precociou...

Puberty is often delayed in children with chronic kidney disease. A 5-year-old boy suffering from severe chronic kidney disease due to a mutation in the TCF2 gene presented with a clinical precocious peripheral puberty 3 weeks after introducing cinacalcet and 2 months after introducing lanthanum carbonate. A retrospective measurement of serum sexual and adrenal hormones before the introduction ...

OBJECTIVE Girls with precocious puberty have high luteinizing hormone (LH) levels and advanced bone age. Obese children enter puberty at earlier ages than do non-obese children. We analyzed the effects of obesity on LH secretion during gonadotropin-releasing hormone (GnRH) tests in girls with precocious puberty. METHODS A total of 981 subjects with idiopathic precocious puberty who had underg...

X-linked adrenal hypoplasia congenita is caused by the mutation of DAX-1 gene (dosage-sensitive sex reversal, adrenal hypoplasia critical region, on chromosome X, gene 1), and can occur as part of a contiguous gene deletion syndrome in association with glycerol kinase (GK) deficiency, Duchenne muscular dystrophy and X-linked interleukin-1 receptor accessory protein-like 1 (IL1RAPL1) gene defici...

Methods We identified 72 girls diagnosed with central precocious puberty, and they were treated with GnRH analogue (GnRHa) to suppress pubertal progression from 1 January 2011 to 31 January 2012. GnRH stimulation tests were done before and 4 weeks after the third dose of the GnRH analogue. Information on clinical manifestations and laboratory data were obtained by reviewing medical records. All...

BACKGROUND/AIMS There are few studies in the literature that have evaluated the etiological factors in boys with central precocious puberty (CPP), and these studies are limited in terms of the sample size. In the present study, we aimed to evaluate the etiological factors in male CPP cases. METHODS One hundred male CPP subjects, aged between 9 months and 10.5 years, were included. The medical...

Precocious puberty (PP) is defined as the development of pubertal changes before the accepted age of its onset. In girls the lower limit of puberty is set at8 year.[1] With PP early secondary sexual changes appear. By definition it is presence of signs at Tanner 2 stage. It starts at 8 year of age and continues till 15 year of age. The signs include elevation of breast and its papilla with the ...

The objectives of treatment for children with central precocious puberty (CPP) are to avoid psychosocial problems caused by early pubertal development and to normalize adult height (AH). A long-acting GnRH analog is the treatment of choice for CPP. GnRH analog administration effectively arrests further development of secondary sex characteristics, slows bone age (BA) maturation, increases puber...

Evaluation of the sellar area was performed with magnetic resonance imaging in 101 patients (age range 0.8-27 years) with hypopituitarism, isolated diabetes insipidus, hypogonadotrophic hypogonadism, and central precocious puberty. The hypopituitary patients (n = 70) included multiple pituitary deficiency (n = 23), pituitary deficiency with diabetes insipidus (n = 5), and isolated growth hormon...

Leydig cell testicular tumors are very rare in children and cause isosexual precocious puberty. Palpable testicular mass or asymmetric testes are common findings on routine examination. We report on a 5-yr-old boy with a Leydig cell tumor of the testis presented with isosexual precocious puberty but no scrotal palpable mass. To our knowledge, this is the first reported Leydig cell tumor in a bo...