For results from a randomised trial to be relevant to practice it is important that the needs of the end users of the trial, health care professionals, policymakers and patients are considered. Key aspects of a trial need to reflect how the intervention would be implemented. PRECIS-2 is an innovative way to display information about a trial’s design, using a wheel with 9 spokes or domains, grap...

In a statistical re-analysis of the data from the Drought Exceptional Circumstances Report, all climate models failed standard internal validation tests for regional droughted area in Australia over the last century. The most worrying failure was that simulations showed increases in droughted area over the last century in all regions, while the observed trends in drought decreased in five of th...

A key challenge in climate modeling is the assessment of the impact of global climate variables on regional weather measurements such as temperature and precipitation. This assessment is usually done by downscaling the output of (coarse resolution) global climate models to regional (high resolution) predictions. There are two independent downscaling pathways: dynamic and statistical. Dynamic do...

On a regional scale, climate variability masks any direct link between external forcings and precipitation values. Thus, the problem of attribution of precipitation changes splits into two distinct steps: understanding how forcings influence circulation patterns and finding relationships between these patterns and the behavior of precipitation. Here, we deal with this second step, by analyzing ...

ABSTRACT Studies regarding deforestation, the hydrological cycle, climate change and fire weather can benefit from detailed simulations provided by regional models (RCM). While much attention has been given to activity in Amazon, few studies have used RCM runs assess risk variables associated occurrence. We evaluated precipitation, temperature a index ensemble of Eta model coupled with three di...

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Conclusion: consider changing "highlights the potential usefulness" of PRECIS-2. Authors: We have revised this section of the abstract completely. Introduction P1 line 38 Spelling Loudon instead of Ludon Authors: This is now addressed P2 line 53, [24] reference to Cochrane review Authors: This is now addressed Method p1 2.1 Line 13 need to insert references [13] [14] Authors: Addressed Method P...