INTRODUCTION Recent work has focused on the hair follicle as the main repository of multipotent stem cells in skin, which is a neat model to study the mechanisms regulating the proliferation, migration and final fate of adult stem cells. This review examines the available literature for its location, molecular markers and multipotency. METHODS Peer-reviewed journals and monographs on the subj...

The primary therapeutic goal for the oncology patient is survival. Recent advances in diagnoses and treatment of neoplasia have resulted in an ever-increasing number of patients being cured and resuming a normal life. However, recognized side effects of treatments used to eradicate malignancies are temporary or permanent sterility. The cryopreservation of ovarian tissue harvested before cancer ...

In the tunicate ovary, both germ cells and follicle cells are generally believed to arise from the ger-minal epithelium (cf., Seeliger (3) and Tucker (5)). The young germ cell moves internally from the periphery of the ovary and, together with several epithelial cells, constitutes the primary follicle. Initially, the germ cell is surrounded only by a flattened layer of epithelium. The cells of ...

background: segmental vitiligo is a small subset albeit persistent form of focal vitiligo with dermatomal distribution and resistant to medical therapy. in recent years, surgical therapy as hair follicle autograft transplantation has been a hot topic in management of segmental vitiligo. in this study, we evaluated the efficacy of this method in segmental vitiligo lesions. methods: the study rec...

introduction: photobiostimulation with low level laser (lll) has been used in medicine for a long time and its effects have been shown in many diseases. some studies have evaluated the effect of lll on androgenic alopecia. one of the most important limitations of the use of lll in the treatment of alopecia is the requirement for multiple sessions, which is hardly accepted by patients. this stud...

in vitro maturation (ivm) is a method that immature oocytes in antral follicles are extracted and matured in laboratry conditions. this review has attempted to provide the current knowledge and recent findings in in vitro maturation of oocytes and highlights the most important factors involved in this process. the review is based on literature reports and the author’s experience. in ivm cycles,...

this study investigated the effect of gnrh analogues on inducing ovulation of dominant follicle (df)and subsequent corpus luteum (cl) lifespan in the presence of norgestomet implant in holstein heifers. onday 6 to 8 of the estrous cycle (day 0 of the experiment), all heifers (n=15) received norgestomet implantfollowed by prostaglandin injection on days 0 and 1. on day 4, group 1 (n=4) and 2 (n=...

Skin and hair follicle stem cell biology is the focus of increasing interest, not least because the adult hair follicle has well defined dermal and epithelial populations that display distinct developmental properties. Recent evidence suggests that a number of adult cell populations have much broader stem cell capabilities than previously thought. To examine whether this applied to the hair fol...

Podocalyxin/Gp135 was recently demonstrated to participate in the formation of a preapical complex to set up initial polarity in MDCK cells, a function presumably depending on the apical targeting of Gp135. We show that correct apical sorting of Gp135 depends on a bipartite signal composed of an extracellular O-glycosylation-rich region and the intracellular PDZ domain-binding motif. The functi...

Podocalyxin/Gp135 was recently demonstrated to participate in the formation of a preapical complex to set up initial polarity in MDCK cells, a function presumably depending on the apical targeting of Gp135. We show that correct apical sorting of Gp135 depends on a bipartite signal composed of an extracellular O-glycosylation–rich region and the intracellular PDZ domain–binding motif. The functi...