Mobile devices gather the communication capabilities as no other gadget. Plus, they now comprise a wider set of applications while still maintaining reduced size and weight. They have started to include accessibility features that enable the inclusion of disabled people. However, these inclusive efforts still fall short considering the possibilities of such devices. This is mainly due to the la...

Genomic studies have revealed that humans possess far fewer protein-encoding genes than originally predicted. These over-estimates were drawn from the inherent developmental and stimuli-responsive complexity found in humans and other mammals, when compared to lower eukaryotic organisms. This left a conceptual void in many cellular networks, as a new class of functional molecules was necessary f...

Vibrational energy harvesters of air-spaced cantilever design, utilizing ferroelectrets as the electroactive element, are a very recent concept. Such systems, based on d 31 piezoelectric effect further studied with improved partially implemented by additive manufacturing. The focus present work is dependence frequency response, resonance frequency, and generated power distance ferroelectret fro...

The lipid second messenger PIP3 was previously thought to be generated exclusively by type I PI 3-kinases. Now, a novel route of PIP3 synthesis, controlled by an unrelated enzyme family, has been discovered, increasing our understanding of the versatility of PIP3 in cellular signalling.

The question of what differentiates physiological from pathological cardiac hypertrophy remains one of the most clinically relevant questions in basic cardiovascular research. The answer(s) to this question will have far-ranging importance in the fight against hypertrophic heart disease and failure. In this issue of the JCI, Perrino et al. have used a unique model system to mimic the pathophysi...

In their excellent Comment (July 21, p. 192), Wen and Wu make a strong case for investing in behaviour change interventions to promote more physical activity in the inactive population. They list several helpful approaches, such as optimizing the available infrastucture and building skills of the inactive. However, their main recommendation is to stress the harms of physical inactivity, and rec...