BACKGROUND In a previous study, we investigated the short-term effects of in utero retinoic acid (RA) exposure on early development at the cleavage stage before implantation to understand the possible roles of RA in blastocyst formation. We designed the present study to investigate the long-term effects of RA exposure on pre-implantation embryos in vivo and in vitro. METHOD To evaluate late p...

BACKGROUND Human long non-coding RNAs (lncRNAs) are an emerging category of transcripts with increasingly documented functional roles during development. LncRNAs and roles during human early embryo development have recently begun to be unravelled. OBJECTIVE AND RATIONALE This review summarizes the most recent knowledge on lncRNAs and focuses on their expression patterns and role during early ...

the activity of mouse endometrial alkaline phosphatase after hyperstimulation and progesterone injection at the implantation time alkaline phosphatase (alp) of endometrium may play a critical function in the development and implantation of embryo. the aim of this study was to determine the localization of endometrial alp activity after hyperstimulation and progesterone injection. thirty adult f...

Successful embryo implantation is a process which requires both a synchronous development and interaction between hatched blastocyst and endometrium. The process of implantation as a scheme is presented in Pic. 1, where the diagram shows a preimplantation stage of embryo and some important factors thought to be necessary for uterine receptivity: COX-2 (cyclooxygenase-2), EGF (epidermal growth f...

Background: While mammalian embryos can adapt to their environments, their sensitivity overshadows their adaptability in suboptimal in vitro conditions. Therefore, the environment in which the gametes are fertilized or to which the embryo is exposed can greatly affect the quality of the embryo and consequently its implantation potential. Objectives:</stro...

STUDY QUESTION Does the application of three different artificial activating stimuli lead to a difference in pre- and post-implantation embryo development in the wobbler mouse, a mouse model with oocyte activation deficient round-headed sperm cells similar to human globozoospermia? SUMMARY ANSWER No gross differences were found between strontium chloride, electrical pulses or ionomycin with r...

background: the luteal phase defect is a common event following the ovarian stimulation. the aim of the present study was to evaluate the use of human chorionic gonadotropine (hcg) and progesterone hormones to improve the luteal phase defect. materials and methods: 60 mice were superovulated routinely with human menopausal gonadotropin (hmg) (7.5u) and hcg (10u). the mice were mated and divided...