Journal of Lipid Research Volume 50, 2009 1663 Copyright © 2009 by the American Society for Biochemistry and Molecular Biology, Inc. Peroxisome proliferator-activated receptors (PPAR) are a family of ligand-activated nuclear receptors that induce transcription of multiple genes encoding proteins involved in fatty acid and glucose metabolism, as well as cell differentiation ( 1, 2 ). Because abn...

Activation of the nuclear receptor/transcription factor, peroxisome proliferator-activated receptor (PPAR ), is a newly defined target for limiting vascular pathologies. PPAR is expressed in human and animal models of vascular disease, with particularly high levels being present in the cells of the neointimal microenvironment. In the present study, we show that intimal smooth muscle cells in vi...

Kriska T, Cepura C, Gauthier KM, Campbell WB. Role of macrophage PPAR in experimental hypertension. Am J Physiol Heart Circ Physiol 306: H26–H32, 2014. First published October 25, 2013; doi:10.1152/ajpheart.00287.2013.—Targeted disruption of the Alox15 gene makes mice resistant to angiotensin II-, DOCA/salt-, and N -nitroL-arginine methyl ester (L-NAME)-induced experimental hypertension. Macrop...

Peroxisome proliferator-activated receptors (PPAR) are nuclear receptors acting as transcription factors on numerous target genes after heterodimerization with the retinoid X receptor. PPAR-alpha and PPAR-gamma may be activated by different agonists, although the endogenous ligands are unknown. Although PPAR-alpha is mainly involved in fatty acid oxidation and expressed in liver, kidney, and sk...

Peroxisome proliferator-activated receptors (PPARs) are essential in glucose and lipid metabolism and are implicated in metabolic disorders predisposing to atherosclerosis, such as diabetes and dyslipidemia. Conversely, antidiabetic glitazones and hypolipidemic fibrate drugs, known as PPAR and PPAR ligands, respectively, reduce the process of atherosclerotic lesion formation, which involves chr...

Citation Shrestha UK, Xia B. Role of Peroxisome Proliferator Activated Receptor-gamma and its Ligands in Inflammatory Bowel Disease. Journal of Advances in Internal Medicine. 2012;01(1)33-38. ABsTRAcT Peroxisome proliferator-activated receptor-gamma (PPAR-γ), a nuclear receptor, is highly expressed in the colonic epithelium in contrast to its impaired expression in the patients with ulcerative ...

The molecular genetics underlying thyroid carcinogenesis is not clear. Recent identification of a PAX8-peroxisome proliferator-activated receptor (PPAR ) fusion gene in human thyroid follicular carcinoma suggests a tumor suppressor role of PPAR in thyroid carcinogenesis. Mice harboring a knockin mutant thyroid hormone receptor (TR PV) spontaneously develop thyroid follicular carcinoma through p...

The nuclear orphan receptor peroxisome proliferator-activated receptor-gamma (PPAR-γ) is expressed in multiple cell types in addition to adipocytes. Upon its activation by natural ligands such as fatty acids and eicosanoids, or by synthetic agonists such as rosiglitazone, PPAR-γ regulates adipogenesis, glucose uptake and inflammatory responses. Recent studies establish a novel role for PPAR-γ s...

Peroxisome proliferator-activated receptor gamma (PPAR-γ), a ligand-activated transcription factor has been investigated as the target for cancer treatment as well as metabolic disorders. Recent studies have demonstrated that PPAR-γ ligands are anti-tumorigenic in prostate cancer due to anti-proliferative and pro-differentiation effects. The aim of this study was to validate PPAR-γ expression i...

Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and food contaminants with known or suspected carcinogenic properties. In this study, we have evaluated whether PAHs activate the early growth response (EGR-1) gene and bind to peroxisome proliferator-activated receptor alpha (PPAR alpha) and delta (PPAR beta/delta) in cell culture systems. Luciferase reporter systems were emp...