Vaginal small interfering RNA (siRNA) delivery provides a promising strategy for the prevention and treatment of vaginal diseases. However, the densely cross-linked mucus layer on the vaginal wall severely restricts nanoparticle-mediated siRNA delivery to the vaginal epithelium. In order to overcome this barrier and enhance vaginal mucus penetration, we prepared spray-dried powders containing s...

in this study the characteristics of two different kinds of la0.6sr0.4co0.2fe0.8o3 (lscf) powders, one in-house synthesized powder by a co-precipitation method and another one purchased from fuel cell materials co. (fcm co., usa), were compared. the co-precipitated powder was prepared by using ammonium carbonate as precipitant with a nh4+/no3- molar ratio of 2 and calcination at 1000c for 1 h....

Omega-3 fatty acids are used in both nutraceuticals and pharmaceuticals in the form of triglycerides and ethyl esters. Administration forms available for omega-3 oil include bulk oil, soft gel capsules, emulsions and some powder compositions. However, the niche omega3 tablets have so far remained unexplored. In the present work direct compaction grade powders comprising omega-3 oil as triglycer...

The pulmonary route has recently attracted attention as a noninvasive administration route for peptide and protein drugs, and an insulin powder for inhalation was approved by authorities in Europe and the USA. The present study examined usefulness of insulin and gene powders for systemic and local inhalation therapy. We prepared several dry insulin powders by spray drying to examine the effect ...

The application of powders to fingerprints has long been established as an effective and reliable method for developing latent fingerprints. Fingerprints developed in situ at a crime scene routinely undergo lifting with specialist tapes and are then stored in evidence bags to allow secure transit and also to preserve the chain of evidence. In a previous study we have shown that exogenous materi...

Talc powder and soapstone may contain asbestos. Random samples taken in the course of the past ten years from materials in use in Germany revealed only low asbestos contents. The present paper is based on analyses of bulk sample carried out by the German Berufsgenossenschaften as part of their prevention activities. In about one quarter of the 57 talc powder samples and 35 soapstone samples ana...

THE P/M INDUSTRY has grown considerably in the past decade. As a result of this growth, more critical components in the automotive, aircraft, tooling, and industrial equipment industries are being considered for manufacture using this technology: This is placing increasingly stringent quality requirements on the final P/M part. Variations in part density, mechanical properties including strengt...

The potential of amphiphilic chitosan formed by grafting octanoyl chains on the chitosan backbone for pulmonary delivery of levofloxacin has been studied. The success of polymer synthesis was confirmed using FT-IR and NMR, whilst antimicrobial activity was assessed against Pseudomonas aeruginosa. Highly dispersible dry powders for delivery as aerosols were prepared with different amounts of chi...