The report of the World Health Organization (WHO) of 2008 defines osteoporosis as a disease characterized by low bone mass and an increased risk of fracture. Postmenopausal osteoporosis is connected to the decrease in estrogens concentration as a result of malfunction of endocrine ovarian function. Low estrogens concentration causes increase in bone demineralization and results in osteoporosis....

OBJECTIVES The objective of this study was to describe the levels of chemerin, irisin and apolipoprotein M (apoM) in women with postmenopausal osteoporosis. METHODS The study included 88 women with postmenopausal osteoporosis. Based on World Health Organization criteria, women with a T-score of ≤ -2.5 were defined as osteoporotic. In this case-control study, postmenopausal women with T-score ...

• Osteoporosis is characterized by low bone mass and microarchitectural deterioration of bone tissue, leading to an increase in bone fragility and the risk of fractures. • In Bulgaria, denosumab 60mg subcutaneous is prescribed for the treatment of postmenopausal osteoporosis (PMO) by specialists (endocrinologists and rheumatologists) and reimbursed for patients with a T-score ≤ -2.5 at one or m...

Osteoporosis is a disorder of the skeleton characterized by réduction in skeletal mass and a conséquent altération in architecture that increases the risk of fracture (1). The disorder is most évident among postmenopausal women, as Albright pointed out more than 50 years ago (2). In many countries osteoporosis has now been recognized as. a major public health problem. It has been estimated that...

OBJECTIVE It has been shown that Insulin-like growth factor-1 (IGF-1) may be related with bone mineral density (BMD) or osteoporosis. But there are few evidences on the role of genetic variation of IGF-1 on the BMD or osteoporosis. We observed the relationship between polymorphisms of IGF-1(rs35767, rs2288377 and rs5742612) with osteoporosis and BMD in the postmenopausal female population in ou...

OBJECTIVES To evaluate the prevalence of osteoporosis in treatment-naïve postmenopausal women, their treatment adherence, and the risk factors for osteoporosis. DESIGN Cross-sectional study of bone density reports, a self-administered health checklist, and computerised consultation records. SETTING Primary care sexual and reproductive health service in Hong Kong. PARTICIPANTS Postmenopaus...

Osteoporosis, especially in postmenopausal women, has a high socioeconomic impact on the individual and on the society. There are several drugs for its prevention and treatment; however, their effectiveness and costs vary considerably. Several economic assessments have been conducted in order to evaluate the most effective strategies. This study aimed at conducting a systematic review of comple...

In the elderly population, osteoporosis is a significant clinical problem leading to disability and even death. Many patients remain untreated, despite effective therapies, because of patients' unwillingness to take current therapies or inability to tolerate the therapies. For this reason, ongoing research continues to search for more effective and tolerable osteoporosis agents. Bazedoxifene is...

OBJECTIVES Osteoprotegerin (OPG) has an important role in bone remodeling, and it has been proposed that the OPG gene might be a candidate gene for osteoporosis predisposition. Several studies have already assessed the connection between OPG gene polymorphism and bone mineral density (BMD). In this study we wanted to analyze the association of two polymorphisms in the OPG gene with BMD and bone...

This paper empirically evaluates the effects of NASDAQ’s $1-minimum-bid-price threshold (known as the one-dollar rule) as part of its listing maintenance criteria. Even though this controversial rule was introduced as early as in September 1991, it remained unexplored by academic research. Empirical evidence compiled in this study suggests that the implementation of this one-dollar rule is just...