OBJECTIVES To retrospectively analyse inflammatory involvement of the ophthalmic arteries in patients with GCA utilizing high-resolution MRI. METHODS A cohort of 50 patients with GCA who had been examined by 1.5 or 3T high-field MRI was analysed retrospectively in a consensus reading for possible involvement of the ophthalmic arteries. In 43 patients, entire orbits were within the field of vi...

Postoperative visual loss is a devastating perioperative complication. The commonest aetiologies are anterior ischaemic optic neuropathy (AION), posterior ischaemic optic neuropathy (PION), and central retinal artery occlusion (CRAO). These appear to be related to certain types of operation, most commonly spinal and cardiac bypass procedures; with the rest divided between: major trauma causing ...

BACKGROUND To describe the first reported case of toxic optic neuropathy secondary to docetaxel (Taxotere®) chemotherapy. CASE PRESENTATION A 53-year-old female presented with predominantly unilateral visual loss, but extensive bilateral visual field defects and bilateral optic nerve head swelling 2 weeks after first dose of docetaxel (Taxotere®) and trastuzumab (Herceptin®) chemotherapy for ...

Purpose: ‘This study describes hemodynamic characteristics of the retrobulbar circulation in ten eyes with acute anterior ischemic optic neuropathy (AION), in order to better understand Ihe natural history of this disease. Methods: Color Doppler imaging was used to measure the peak systolic blood flow velocities and vascular resistance (resistive index) within the central retinal, ophtalmic, an...

Purpose: ‘This study describes hemodynamic characteristics of the retrobulbar circulation in ten eyes with acute anterior ischemic optic neuropathy (AION), in order to better understand Ihe natural history of this disease. Methods: Color Doppler imaging was used to measure the peak systolic blood flow velocities and vascular resistance (resistive index) within the central retinal, ophtalmic, an...

Purpose: ‘This study describes hemodynamic characteristics of the retrobulbar circulation in ten eyes with acute anterior ischemic optic neuropathy (AION), in order to better understand Ihe natural history of this disease. Methods: Color Doppler imaging was used to measure the peak systolic blood flow velocities and vascular resistance (resistive index) within the central retinal, ophtalmic, an...

In this review, we comprehensively describe ophthalmic diseases with mitochondrial DNA mutation such as Leber's hereditary optic neuropathy (LHON), progressive external ophthalmoplegia (PEO) and Kearns-Sayre Syndrome (KSS). Ocular involvement is a prominent clinical feature of various mitochondrial diseases as well. The known mitochondrial disorders such as Mitochondrial encephalomyopathy, lact...

In systemic lupus erythematosus (SLE), ocular involvement is common (prevalence up to 30%) but extremely varied.The most common manifestation is keratoconjunctivitis sicca (in about 25%). Though posterior segment disease is not uncommon, choroidal involvement and optic neuropathy are rare. Visual loss from neuro-ophthalmic involvement is often due to lupus optic neuropathy. Less than five perce...