This study investigates the mechanism of protein particle formation during ultrafiltration/diafiltration (UF/DF), finding that agitation drives particle formation by promoting protein-interface adsorption and desorption. Low conductivity and the presence of surfactant reduced the level of particle formation in small-scale stirring studies, and the same trends were observed in pumping and UF/DF....

Theaim of this study was to optimise processing parameters in the preparation ofbudesonide nanocrystals by a miniature media milling process performed at labscale. Using Polysorbate 80 as surfactant choice stabilizer, effectof bead size, time and stabilizer concentration on budesonideparticle size determined. Particle decreased with smaller beadsize longer time. However, no significant further ...

In this study, an alternative aqueous isopropyl alcohol-free fountain solution for sheet-fed offset printing is prepared comprising 5 w/w% McIlvaine's buffer system pH control, 0.3 Polysorbate 80 as a surfactant, 1 magnesium nitrate hexahydrate conductivity agent and 10 ethylene glycol mono-butyl ether additional wetting agent. The percentages of each composition are active then adjusted to 100...

BACKGROUND The Canadian-accredited post-baccalaureate Doctor of Pharmacy program at Qatar University trains pharmacists to deliver advanced patient care. Emphasis on acquisition and development of the necessary knowledge, skills, and attitudes lies in the curriculum's extensive experiential component. A campus-based oral comprehensive examination (OCE) was devised to emulate a clinical viva voc...

β-Carotene has been established as a known free radical scavenger with chain-breaking antioxidant properties. It has been documented for the treatment of epileptic convulsions at a 200 mg/kg body weight dose. The reported pathogenesis for epileptic convulsions is oxidative stress. Hence, experimental epileptic convulsions via oxidative stress was induced in albino mice epileptic models (maximal...

Polysorbates (PS) are added to biopharmaceutical formulations stabilize proteins and monoclonal antibodies (mAbs) prevent aggregation, denaturation, surface adsorption. Polysorbate analysis can be challenging because of their inherent complexity, polydispersity, presence in matrices containing high concentrations other excipients such as sugars, amino acids, salts, buffers. This instalment “Bio...

We report a simple and scalable method for the separation of semiconducting single-walled carbon nanotubes (SWNTs) from metallic SWNTs using magnetic nanoparticles (MNPs) functionalized with polycationic tri-aminated polysorbate 80 (TP80). MNPs-TP80 are selectively adsorbed on acid-treated semiconducting SWNTs, which makes the semiconducting SWNTs be highly concentrated to over 95% under a magn...