Aluminum is a neurotoxin, yet infants and young children are repeatedly injected with aluminum adjuvants from multiple vaccines during critical periods of brain development. Numerous studies provide credible evidence that aluminum adversely affects important biological functions and may contribute to neurodegenerative and autoimmune disorders. It is impossible to predetermine which vaccinated b...

Intravenous desferrioxamine (DFO) is the method commonly used to treat aluminum toxicity. This laboratory has developed a hollow fiber device with immobilized DFO, an "Aluminum DFO-HP" (DFO-HP), for the purpose of removing aluminum without the chelator (DFO) entering the blood. With Food and Drug Administration approval, a polysulfone DFO-HP, placed in the extracorporeal circuit in series with ...

The mechanism behind the adjuvant effect of aluminum salts is poorly understood notwithstanding that aluminum salts have been used for decades in clinical vaccines. In an aqueous environment and at a nearly neutral pH, the aluminum salts form particulate aggregates, and one plausible explanation of the lack of information regarding the mechanisms could be the absence of an efficient method of t...

Polynuclear coordination clusters can be readily arranged in cluster-based polymers (CCPs) by appropriate bridging linkers. This review provides an overview of our recent developments exploring structurally well-defined Mn/Fe-oxo pivalate and isobutyrate building blocks the formation CCPs assemblies with emphasis on synthetic strategies magnetic properties.

A new click chemistry generated artificial metallonuclease is reported in the Research Article by Andrew Kellett et al. (e202305759). The oxidative DNA damaging properties of a polynuclear copper binding ligand called TC-Thio demonstrated. Copper-TC-Thio binds minor groove genomic and promotes damage via superoxide linked mechanism. inset picture shows ions, bound to ligand, melting into duplex...

Interactions between fluorine (as F) and aluminum (as Al) have recently attracted much attention following reports of their possible involvement in Alzheimer’s disease (AD). An inverse correlation has been demonstrated between the incidence and severity of AD and the level of fluorine in drinking water.1-4 Aluminum has long since been implicated in the etiopathology of AD, and neurotoxicity stu...