BACKGROUND Most KPC-producing organisms have maintained susceptibility to polymyxins; however, development of resistance to polymyxins has been increasingly reported. One potential treatment modality is to optimize the use of combination therapy. Therefore, we evaluated the in vitro activity of doripenem, colistin sulfate, polymyxin B alone and in combination against KPC- producing K. pneumonia...

We currently face a lack of new antimicrobial therapies in an era of increasingly common multidrug-resistant (MDR) bacteria. The polymyxins have become last-line treatments for patients with MDR bacterial infections. An increasing body of published literature has attempted to answer questions about dosing, pharmacology, and susceptibility testing of these drugs, yet each takes for granted purit...

This article reviews three classes of antibacterial agents that are uncommonly used in bacterial infections and therefore can be thought of as special-use agents. The polymyxins are reserved for gram-negative bacilli that are resistant to virtually all other classes of drugs. Rifampin is used therapeutically, occasionally as a companion drug in treatment of refractory gram-positive coccal infec...

Introduction: There has been a rise in the reappearance of multidrug-resistant Gram-negative bacteria recent years. Using polymyxins, such as colistin, last-line treatment for these infections led to renewed interest toxic effects this drug. Case Presentation: In case report, we present neurological signs and symptoms developed patient with history cervical cancer four five hours after receivin...

independent pathways. through both phoP-dependent and RpoS (sigma(S)) independent and occurs polymyxin B in Salmonella typhimurium is resistance to the antimicrobial peptide Starvation-and Stationary-phase-induced