The spread of antibiotic-resistant pathogens requires new treatments. Small molecule precursor compounds that produce oxidative biocides with well-established antimicrobial properties could provide a range of new therapeutic products to combat resistant infections. The aim of this study was to investigate a novel biomaterials-based approach for the manufacture, targeted delivery and controlled ...

Intent of this study was to explore the potential application of polymerin, the polymeric, dissolved organic matter fraction from olive oil wastewaters, in technologies aimed at remediating hydrophobic organic compounds (HOCs) point-source pollution. Phenanthrene binding with polymerin was investigated. Moreover, the effect of addition of micro and nanoscale aluminum oxides (Al2O3) was studied,...

Here we report a novel approach for preparation of a 6-day transdermal drug delivery system (TDDS) as treatment for mild to moderate Alzheimer’s disease. The spray drying method was used to prepare microparticles containing the anti-Alzheimer drug. The content of the drug was determined by High Performance Liquid Chromatography (HPLC) method. The morphology and size range of the microparticles ...

Objectives: The aim of the present study was to evaluate effects of various polymers on the release of a water soluble drug by using spray drying technique of microencapsulation. Methods: Spray drying is a single step technique, less time is required and loading efficiency is not affected by the nature of the drug whether hydrophilic or hydrophobic. Eudragit RS 30D, RL 30D and Ethylcellulose (S...

The aim of the present study was to develop novel Mycobacterium bovis bacille Calmette-Guérin (BCG)-loaded polymeric microparticles with optimized particle surface characteristics and biocompatibility, so that whole live attenuated bacteria could be further used for pre-exposure vaccination against Mycobacterium tuberculosis by the intranasal route. BCG was encapsulated in chitosan and alginate...

Protein drugs have low bioavailability after oral administration, which is due in part to fast transit of the drugs or drug delivery vehicles through the gastrointestinal tract. Increasing the time that the drugs spend in the intestine after dosing would allow for greater absorption and increased bioavailability. We developed a formulation strategy that can be used to prolong intestinal retenti...

One common approach to generate lightweight materials with high specific strength and stiffness is the incorporation of stiff hollow microparticles (also known as bubbles or microballoons) into a polymeric matrix. The mechanical properties of these composites, also known as syntactic foams, greatly depend on those of the hollow microparticles. It is critical to precisely control the properties ...

objectives: platelets are anucleated fragments derived from megakaryocytes. it has been demonstrated that platelets play a role in hemostasis and innate immunity. in addition, platelets have a cd40 ligand which is an important molecular marker in motivating immune cells. thus, platelets also have a role in adaptive immunity as seen by their ability to activate b cells. since human platelet micr...

Cancer vaccines that use tumor lysate (TL) as a source of tumor-associated antigens (TAAs) have significant potential for generating therapeutic anti-tumor immune responses. Vaccines encompassing TL bypass the limitations of single antigen vaccines by simultaneously stimulating immunity against multiple TAAs, thereby broadening the repertoire of TAA-specific T-cell clones available for activati...

The modern pharmaceutical technology is not conceivable without plasticized polymers. The pharmaceutical applications of polymers range from packaging materials or auxiliary substances in conventional dosage forms to membranes or matrices modifying and controlling the drug release characteristics in therapeutic systems. Recently, a great variety of plasticized polymeric systems have been studie...