Nanoparticles ranging below several 10 nm such as metals, semiconductors and metal oxides are of great interest for a wide variety of applications in the field of information, energy, environmental and medical technologies due to their unique size, composition and structure. In this review article synthesis method of nanosized particles is briefly described including their application in today’...

The objective of this work was to develop sustained release formulation for hydrophilic drugs with minimal burst effects. For this purpose, nanoparticles of a hydrophilic drug were produced using supercritical CO2, which were then encapsulated into polymer microparticles using an anhydrous method, followed by studying their sustained in-vitro drug release. A hydrophilic drug, dexamethasone phos...

During the last decade, conjugated polymers have emerged as an interesting class of fluorescence imaging probes since they generally show high fluorescence brightness, high photostability, fast emission rates, non-blinking behavior and low cytotoxicity. The main concern related to most conjugated polymers is their lack of hydrophilicity and thereby poor bio-availability. This can, however, be o...

Swellable elementary osmotic pump (SEOP)utilizes the osmotic pressure and polymer-swelling force to deliver drugs to the GI tract in a reliable and reproducible manner.Metoprolol and ramipril are one of the combinationsindicated in the management of hypertension in patients with heart failure and post myocardial infarction. This combination was selected to develop SEOP to release the drugs cont...

Op18/stathmin (Op18), a conserved microtubule-depolymerizing and tubulin heterodimer-binding protein, is a major interphase regulator of tubulin monomer-polymer partitioning in diverse cell types in which Op18 is abundant. Here, we addressed the question of whether the microtubule regulatory function of Op18 includes regulation of tubulin heterodimer synthesis. We used two human cell model syst...

Polyvinyl chloride (PVC)-based solid-contact ion-selective electrodes (SC-ISEs), responding to propranolol hydrochloride (Pr+) and lidocaine hydrochloride (Ld+) cations as the model drugs with potassium tetrakis(4-chlorophenyl) borate (KTpClPB) as the ion exchanger, were studied. Different drug-polymer solutions were prepared with the model drugs, using different blend ratios of ethylcellulose ...

One of the greatest challenges facing the pharmaceutical industry is the design and development of suitable delivery systems to overcome poor dissolution profile for insoluble drugs. Different formulation approaches including particulate systems, pH alterations and co solvents have been investigated in an attempt to determine the critical formulation parameters to improve dissolution and solubi...