Polyglycerols are a class of multifunctional polymers obtained from the polymerization glycidol and its derivatives. Unlike poly(ethylene glycol) (PEG), which is most common polyether, polyglycerols can exhibit many functionalities on their side chains be renewable resources, mainly glycerol. Hereby, this study will focus glycidyl carbamates, new monomers readily available glycerol carbonate, c...

The aims of this project were firstly to develop a protocol for the iterative synthesis of polyethers on a polymeric support, using suitably protected monomers. The synthesis of cyclic ethers by an intramolecular cyclisation/cleavage from the polymeric support, utilising a sulfonyl chloride linker, was also desired. The final aim was to develop a method for reductive amination on a polymeric su...

Brevetoxins (PbTx) and brevenal are marine ladder-frame polyethers. PbTx binds to activates voltage-gated sodium (Nav) channels in native tissues, whereas antagonizes these actions. However, the effects of on recombinant Nav channel function have not been systematically analyzed. In this study, PbTx-3 modulation tissue-representative subtypes Nav1.2, Nav1.4, Nav1.5, Nav1.7 were examined using a...