The aim of this study was to develop a multilayer (core/coat) dosage form via co-extrusion, the core providing sustained drug release and the coat immediate drug release. In this study polymers were selected which can be combined in a co-extruded dosage form. Several thermoplastic polymers were hot-melt extruded and evaluated for processability and macroscopic properties (surface smoothness, di...

OBJECTIVE AND IMPORTANCE We have developed novel biodegradable polymer implants by using the rapid prototyping technology fused deposition modeling. Early results of a clinical pilot study for cranioplasty are presented. CLINICAL PRESENTATION Five patients with the diagnosis of chronic subdural hematoma were included in the study. After trephination and evacuation of the subdural hematoma, bu...

Polymeric scaffolds used in regenerative therapies are implanted in the damaged tissue and submitted to repeated loading cycles. In the case of articular cartilage engineering, an implanted scaffold is typically subjected to long-term dynamic compression. The evolution of the mechanical properties of the scaffold during bioresorption has been deeply studied in the past, but the possibility of f...

Poor distribution of antigen/adjuvant to target sites and inadequate induction of T cell responses remain major challenges in cancer immunotherapy because of the lack of appropriate delivery systems. Nanocarrier-based antigen delivery systems have emerged as an innovative strategy to improve vaccine efficacy. Here we present polymeric hybrid micelles (PHMs) as a simple and potent antigen/adjuva...

Free-standing nanocellulosic films (nanopapers) emerge as attractive sustainable materials to replace traditional plastics. However, the moisture sensitivity of cellulose and its poor dispersion in hydrophobic polymers are challenges widespread application. Harnessing inherent properties cellulose, lignin, polycaprolactone, a Pickering emulsion approach is proposed produce multifunctional nanof...

In this study, the relation between the permeation properties and structural characteristics of thermoplastic polyurethane based on polycaprolactone diol, TPU(PCL), and polycaprolactone (PCL) blends is investigated. for the purpsoes of this study, PU, PCL, and TPU/PCL blends containing 20 wt.% and 40 wt.% PCL were prepared via a solution blending method. The miscibility and good distribution of...