BACKGROUND Current modalities of renal replacement therapy allow only a limited removal of larger, possibly toxic molecules, which accumulate in uraemia. Recently, a haemodiafilter has been made available with the new, high-flux, polyethersulfone-based membrane DIAPES HF800. We performed a study to compare DIAPES HF800 with two conventional high-flux membranes in on-line haemodiafiltration (HDF...

Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5'-WGWWCW-3' (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide deriva...

Polyamide polymers have moderate mechanical properties, excellent wear resistant properties, and solvents. However, polyamides have some disadvantages such as notch sensitivity and high water absorption. Generally, polyamides are ductile in the un notched state but they show brittle behavior in the state of notched impact. Some disadvantages of polyamides can be improved by some fillers and add...

When targeted to sequences adjacent to a TATA element, pyrrole-imidazole (Py-Im) polyamides inhibit the DNA binding activity of TATA box binding protein (TBP) and basal transcription by RNA polymerase II. In the present study, we scanned the human immunodeficiency virus type 1 promoter for polyamide inhibition of TBP binding and transcription using a series of DNA constructs in which a polyamid...

Radiation processing involves the use of natural or manmade sources of high energy radiation on an industrial scale. The principle of radiation processing is the ability of high energy radiation to produce reactive cations, anions and free radicals in materials. The industrial applications of the radiation processing of plastics and composites include polymerization, cross-linking, degradation ...

Androgen receptor (AR) is essential for the growth and progression of prostate cancer in both hormone-sensitive and hormone-refractory disease. A DNA-binding polyamide that targets the consensus androgen response element binds the prostate-specific antigen (PSA) promoter androgen response element, inhibits androgen-induced expression of PSA and several other AR-regulated genes in cultured prost...

The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor-DNA interfaces, and modulate gene expression pathways in cell culture experiments. The (18)F-radiolabeled polyamides were prepared by oxime lig...

The weight of a device is an ergonomic criterion as well. Devices that are carried and operated by people may not exceed a weight of 5 kg (11 lbs.). Previously, this was achieved by using lowdensity materials, such as aluminum or polyamide. An additional weight reduction, however, can be obtained through the use of ABS plastics and the FDM process. The density differences of ABS and polyamide d...