Damage to peripheral nerves often cannot be repaired by the juxtaposition of the severed nerve ends. Surgeons have typically used autologous nerve grafts, which have several drawbacks including the need for multiple surgical procedures and loss of function at the donor site. As an alternative, the use of nerve guidance channels to bridge the gap between severed nerve ends is being explored. In ...

In this study, Poly (L-lactic acid)/Captopril composite nanofiber membranes were electrospun for drug delivery. Different mass fractions of Poly (L-lactic acid), different ratios of Captopril and the influences of PEG4000 added in the spinning solution are discussed. The morphology, chemical components, the surface areas and pore sizes, wettability of the composite nanofiber membranes were inve...

The properties of biodegradable lactic acid based poly(ester-urethanes), PEU, were chemically and physically modified and the structure-property relationships investigated. The heat resistance of PEU was improved by copolymerization of lactic acid with DL-mandelic acid. The glass transition temperature of poly(L-lactic acid-co-DL-mandelic acid-urethanes) showed a marked increase with increased ...

Prostaglandin E₂ receptor subtype 4 (EP4) agonists are known to reduce intestinal inflammation and enhance epithelium regeneration. We explored the possibility of colonic delivery of an EP4 agonist, 2-[(4-{[2-((1R,2R,3R)-3-hydroxy-2-{(1E,3S)-3-hydroxy-4-[3-(methoxymethyl)phenyl]but-1-enyl}-5-oxocyclopentyl)ethyl]sulfanyl}butanoyl)oxy]ethyl nonanoate (ONO-AE2-724), using poly(lactic-coglycolic a...

Alkali-treated bagasse fiber was used as a process variable for optimization of the properties polybutylene succinate/poly(lactic acid)-based biocomposites using Box-Behnken design (BBD) and response surface methodology (RSM). The optimum conditions three factors, i.e., NaOH-treated (0.55 to 1.65 g), succinate (1.1 2.3 poly(lactic acid) (2.2 3.4 g) on bending strength biocomposite were investig...